91869-68-0Relevant academic research and scientific papers
Ultrasound assisted synthesis of 1,5-disubstituted pyrazole using Cu(I) catalyst
Pise, Ashok S.,Burungale, Arvind S.,Devkate, Santosh S.
, p. 575 - 579 (2020/02/06)
A new efficient and convenient approach towards the synthesis of pyrazole is described. The α,β-unsaturated cyanoesters were obtained from substituted benzaldehyde and ethyl cyanoacetate by reported methods. 1,5-Disubstituted pyrazoles were synthesized fr
Cycloisomerization of acetylenic oximes and hydrazones under gold catalysis: Synthesis and cytotoxic evaluation of isoxazoles and pyrazoles
Jeyaveeran,Praveen, Chandrasekar,Arun,M Prince,Perumal
, p. 73 - 83 (2016/02/09)
The synthesis of substituted isoxazoles and pyrazoles through a general cycloisomerization methodology has been reported. The capability of gold(III) chloride to promote cycloisomerization of both α, β-acetylenic oximes and α, β-acetylenic hydrazones is t
Novel crown ether functionalized imidazolium-based acidic ionic liquid catalyzed synthesis of pyrazole derivatives under solvent-free conditions
Patil, Dayanand,Chandam, Dattatraya,Mulik, Abhijeet,Jagdale, Suryabala,Patil, Prasad,Deshmukh, Madhukar
, p. 6843 - 6858 (2015/08/18)
Abstract An innovatively designed novel crown ether functionalized imidazolium-based reusable acidic ionic liquid [crown ether MIm] [HSO4] has been efficiently implemented for the synthesis of pyrazole derivatives using various substituted enaminones, hydrazine hydrate and phenyl hydrazine under solvent-free conditions. Structural novelty and task efficiency of the catalyst, high yields of desired products, greener approach attributing high atom economy and solvent-free conditions render this protocol suitable to cope with the current demand in contemporary organic chemistry. The inventive idea of utilizing crown ether functionalized ionic liquid as a catalyst was for the first time demonstrated in this protocol.
Synthesis of pyrazoles via CuI-mediated electrophilic cyclizations of α,β-alkynic hydrazones
Zora, Metin,Kivrak, Arif
experimental part, p. 9379 - 9390 (2012/01/06)
Synthesis of pyrazoles via electrophilic cyclization of α,β-alkynic hydrazones by copper(I) iodide is described. When treated with copper(I) iodide in the presence of triethylamine in refluxing acetonitrile, α,β-alkynic hydrazones, prepared readily from hydrazines and propargyl aldehydes and ketones, undergo electrophilic cyclization to afford pyrazole derivatives in good to excellent yields. The reaction appears to be general for a variety of α,β-alkynic hydrazones and tolerates the presence of aliphatic, aromatic, and ferrocenyl moieties with electron-withdrawing and electron-donating substituents.
New Synthesis of Pyrazole and Isoxazole Derivatives
Molina, P.,Fresneda, P. M.
, p. 461 - 464 (2007/10/02)
A convenient synthesis of 5-aryl-1-phenylpyrazoles and 5-arylisoxazoles, from readily available ketimine 1 dimethylformamide dimethylacetal and phenylhydrazine or hydroxylamine, is described.
Thermolysis of Polyazapentadienes. Part 7. An Unambiguous Route to 7-Substituted Quinolines from Cinnamaldehyde Derivatives
Hickson, Clare L.,McNab, Hamish
, p. 1569 - 1572 (2007/10/02)
Flash vacuum pyrolysis of the cinnamaldehyde phenylhydrazone derivatives (4) - (6) or O-alkyl oxime derivatives (7) - (12) at 600 -650 deg C and 10-2 - 10-3 Torr leads to approximately equal quantities of cinnamonitriles and quinolines.Use of a p-substituted cinnamaldehyde derivatives gives the appropriate 7-substituted quinoline in high isomeric purity; the reactions take place via conjugated iminyl radicals.
