918802-82-1

Basic information

• Product Name: N-galactosylamino-N'-phenylpiperazine
• Synonyms: N-galactosylamino-N'-phenylpiperazine
• CAS NO: 918802-82-1
• Molecular Weight: 502.519
• Mol File: 918802-82-1.mol

Chemical Properties

• CAS DataBase Reference: N-galactosylamino-N'-phenylpiperazine(CAS DataBase Reference)
• NIST Chemistry Reference: N-galactosylamino-N'-phenylpiperazine(918802-82-1)
• EPA Substance Registry System: N-galactosylamino-N'-phenylpiperazine(918802-82-1)

Safety Data

• Hazardous Substances Data: 918802-82-1(Hazardous Substances Data)

Upstream product

• 62-53-3 aniline 
• 92-54-6 4-phenyl-1-piperazine 
• 96-82-2 lactobionic acid 

Downstream Products

• 918802-83-2 4-{4-[(2R,3R,4R,5R)-2,3,5,6-Tetrahydroxy-4-((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-hexanoyl]-piperazin-1-yl}-benzaldehyde 

Relevant articles and documents

Study on synthesis and biological activity of a galactosylated piperazinyl porphyrin

In order to obtain an carcinoma-selective drug, the synthesis and characterization of 5,10,15,20-tetra[4-(4′-galactosylpiperazinyl)phenyl]porphyrin (TGPP) is reported. The biological activity on cancer cells and the pharmacokinetics are also reported as preliminary results showing a very high liver to skin ratio and short retention time in tissues, and thus promising activity in photodynamic therapy.

Synthesis of lactosylated piperazinyl porphyrins and their hepatocyte-selective targeting

The aim of this work was the synthesis of a new family of lactosylated piperazinly porphyrins in which the galactoside piperazine moieties are linked to the tetra- and monophenyl ring by an amide bond. Two compounds were designed, synthesized, and characterized by 1H-nuclear magnetic resonance (1H-NMR), ultraviolet (UV)-visible, and matrix-assisted laser desorption/ionization (MALDI) mass spectra. The biological activity on cancer cells and the pharmacokinetics have also been evaluated, showing a very high liver-to-skin ratio and short retention time in tissues. It is suggested that such novel lactosylated piperazinyl porphyrins, as potential hepatocyte-selective targeting drugs, thus show promising activity in photodynamic therapy. Birkha?user Boston 2007.