918802-83-2Relevant academic research and scientific papers
Synthesis of lactosylated piperazinyl porphyrins and their hepatocyte-selective targeting
Li, He-Ping,Cao, Zhong,Xiao, Hua-Wu
, p. 28 - 38 (2008/04/01)
The aim of this work was the synthesis of a new family of lactosylated piperazinly porphyrins in which the galactoside piperazine moieties are linked to the tetra- and monophenyl ring by an amide bond. Two compounds were designed, synthesized, and characterized by 1H-nuclear magnetic resonance (1H-NMR), ultraviolet (UV)-visible, and matrix-assisted laser desorption/ionization (MALDI) mass spectra. The biological activity on cancer cells and the pharmacokinetics have also been evaluated, showing a very high liver-to-skin ratio and short retention time in tissues. It is suggested that such novel lactosylated piperazinyl porphyrins, as potential hepatocyte-selective targeting drugs, thus show promising activity in photodynamic therapy. Birkha?user Boston 2007.
Study on synthesis and biological activity of a galactosylated piperazinyl porphyrin
Li, He-Ping
, p. 6298 - 6301 (2007/10/03)
In order to obtain an carcinoma-selective drug, the synthesis and characterization of 5,10,15,20-tetra[4-(4′-galactosylpiperazinyl)phenyl]porphyrin (TGPP) is reported. The biological activity on cancer cells and the pharmacokinetics are also reported as preliminary results showing a very high liver to skin ratio and short retention time in tissues, and thus promising activity in photodynamic therapy.
