918868-38-9Relevant academic research and scientific papers
Total synthesis of (+)-migrastatin
Reymond, Sebastien,Cossy, Janine
, p. 4800 - 4804 (2006)
(+)-Migrastatin, an antimetastatic agent, was synthesized by using three ruthenium-catalyzed metathesis reactions: a ring-closing metathesis (RCM) to control the (Z)-trisubstituted double bond at C11-C12, another RCM at C6-C7 to establish the macrolactone
Synthetic Studies toward the C14-C29 Fragment of Mirabalin
Cornil, Johan,Echeverria, Pierre-Georges,Reymond, Sébastien,Phansavath, Phannarath,Ratovelomanana-Vidal, Virginie,Guérinot, Amandine,Cossy, Janine
supporting information, p. 4534 - 4537 (2016/09/28)
A convergent synthesis of one isomer of the C14-C29 fragment of mirabalin is disclosed. The key steps include a Marshall allenylation, a Mukaiyama aldol reaction and a Crimmins aldolization, which allow the control of 10 out of 25 stereogenic centers pres
Synthesis of migrastatin and its macrolide core
Reymond, Sébastien,Cossy, Janine
, p. 5918 - 5929 (2008/02/02)
Migrastatin and its macrolactone subunit are potent antimetastatic agents. Both were synthesized by using a ring-closing metathesis (RCM) to establish the macrolactone core, and the control of the (Z)-trisubstituted double bond at C11-C12 was achieved by?
