91904-57-3Relevant articles and documents
Method for catalyzing amino protection by imidazole hydrochloride
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Paragraph 0039-0043, (2019/08/01)
The invention provides an amino protection method which realizes multi-substituted amino protection by using imidazole hydrochloric acid as an accelerator to push derivatives of primary amine, secondary amine and acrylamide to perform Michael addition at a relatively low temperature, wherein the imidazole hydrochloric acid promotes a carbon-nitrogen bond to crack back to the derivatives of primaryamine and acrylamide at a high temperature. The method provided by the invention is simple and economical, high in practicability, free of any other catalysts or additives, capable of protecting amino to have good functional group tolerance and excellent yield and purity, short in reaction time, free from harsh reaction conditions and suitable for industrial production.
Silica gel accelerated aza-Michael addition of amines to α,β-unsaturated amides
You, Lisha,Feng, Song,An, Rui,Wang, Xinhong,Bai, Donglu
, p. 5147 - 5149 (2008/12/20)
A novel method to synthesize β-amino amide has been developed via conjugated addition of amine to bulky α,β-unsaturated amides promoted by silica gel. The silica gel worked efficiently to accelerate the reaction and afforded the related adduct in good to excellent yield.
