2675-94-7

Usage

Uses

Used in Pharmaceutical Industry:
N,N-DIETHYLACRYLAMIDE is used as a monomer for the synthesis of polymers that are employed in drug delivery systems. These polymers can be designed to have specific properties, such as thermal responsiveness and tunable lower critical solution temperatures (LCSTs), which can enhance the delivery and release of drugs in the body.
Used in Polymer Science:
N,N-DIETHYLACRYLAMIDE is used as a monomer for the development of thermal responsive polymers. These polymers can change their properties in response to temperature, making them useful in various applications, such as smart materials and temperature-sensitive drug delivery systems.
Used in Material Science:
N,N-DIETHYLACRYLAMIDE is used as a monomer for the creation of solutions with specifically tuned LCSTs. These solutions can be used in various applications, such as temperature-sensitive coatings, adhesives, and hydrogels, where the phase behavior of the solution can be controlled by adjusting the temperature.

InChI:InChI=1/C7H13NO/c1-4-7(9)8(5-2)6-3/h4H,1,5-6H2,2-3H3

Upstream product

• 57-57-8 β-Propiolactone 
• 109-89-7 diethylamine 
• 27945-00-2 N,N-diethyl-β-diethylaminopropionic acid amide 
• 28226-88-2 3-chloro-N,N-diethylpropanamide 
• 408318-10-5 2-acetoxy-propionic acid diethylamide 
• 814-68-6 acryloyl chloride 
• 7446-81-3 sodium 2-propenoate 
• 79-10-7 acrylic acid 
• 16276-72-5 Phosphorigsaeure-n-butylester-N,N-diaethylamid 
• 5351-01-9 methyl 3-(N,N-diethylamino)propionate 
• 292638-85-8 acrylic acid methyl ester 
• 74-85-1 ethene 
• 201230-82-2 carbon monoxide 
• 74-86-2 acetylene 

Downstream Products

• 51867-47-1 3-{[2-(2,5-Dimethoxy-4-methyl-phenyl)-ethyl]-methyl-amino}-N,N-diethyl-propionamide 
• 51761-59-2 Diethyl-N-phenyl-P-<2-(diethylcarbamoyl)ethyl>-phosphonimidat 
• 51761-60-5 Diethyl-N-p-tolyl-P-<2-(diethylcarbamoyl)ethyl>-phosphonimidat 
• 28227-12-5 (2-Diethylcarbamoyl-ethyl)-phenyl-phosphinic acid 2,2,2-trichloro-1,1-dimethyl-ethyl ester 
• 28227-13-6 (2-Diethylcarbamoyl-ethyl)-p-tolyl-phosphinic acid 2,2,2-trichloro-1,1-dimethyl-ethyl ester 
• 10385-08-7 heptanoic acid diethylamide 
• 27829-46-5 (E)-N,N-diethyl-3-phenylacrylamide 
• 107771-02-8 3-benzylamino-N,N-diethyl-propionamide 
• 93101-90-7 (2E,4E)-2-Diethylamino-5-phenyl-penta-2,4-dienenitrile 
• 93101-88-3 3-Benzenesulfonyl-N,N-diethyl-thiopropionamide 
• 93101-86-1 (E)-4-Benzenesulfonyl-2-diethylamino-but-2-enenitrile 
• 344890-72-8 (E)-4-Benzenesulfonyl-2-diethylamino-hepta-2,6-dienenitrile 
• 344890-71-7 (E)-4-Benzenesulfonyl-2-diethylamino-hept-2-enenitrile 
• 344892-32-6 (E)-4-Benzenesulfonyl-2-diethylamino-7-methyl-octa-2,6-dienenitrile 

Relevant academic research and scientific papers

Asymmetric Allylation Catalyzed by Chiral Phosphoric Acids: Stereoselective Synthesis of Tertiary Alcohols and a Reagent-Based Switch in Stereopreference

The substrate scope of the asymmetric allylation with zinc organyls catalyzed by 3,3-bis(2,4,6-triisopropylphenyl)-1,1-binaphthyl-2,2-diyl hydrogenphosphate (TRIP) has been extended to non-cyclic ester organozinc reagents and ketones. Tertiary chiral alcohols are obtained with ee's up to 94% and two stereogenic centers can be created. Compared to the previous lactone reagent the stereopreference switches almost completely, proving the fact that the nature of the organometallic compound is of immense importance for the asymmetry of the product. (Figure presented.).

Method for catalytically synthesizing acrylamide compound by MOFs-derived zirconium-based ternary oxide solid acid

The invention provides a catalytic synthesis of acrylamide compounds with zirconium-based ternary oxide solid acid as a catalyst, and the low-temperature activity is good. In the synthesis process, the acid is small, the reaction conditions are mild and controllable, the byproducts are few, the reaction yield is effectively improved, the purity is high, the quality is good, and the method is suitable for large-scale production.

Iridium-Catalyzed Asymmetric Hydroalkenylation of Norbornene Derivatives

Transition-metal-catalyzed asymmetric hydroalkenylation of alkenes provides an atom-economical method to build molecular complexity from easily available materials. Herein we report an iridium-catalyzed asymmetric hydroalkenylation of unconjugated alkenes with acrylamides and acrylates. The catalytic hydroalkenylation of norbornene derivatives occurred to form products with allylic stereocenters with high chemo-, regio-, and stereoselectivities. DFT calculations revealed that the migratory insertion is irreversible and the enantiodetermination step.

Process for Productions of Formamides and Acrylamides

This invention relates to performance chemicals field, it discloses a novel and green process for simultaneous productions of formamides as well as mono- and multi-functional acrylamides under very mild conditions and with high efficiency. These substances are widely useful as industrial solvents or raw materials, in particular acrylamides are important olefinically-unsaturated polymerizable monomers in photo-curing materials.

Clickable coupling of carboxylic acids and amines at room temperature mediated by SO2F2: A significant breakthrough for the construction of amides and peptide linkages

The construction of amide bonds and peptide linkages is one of the most fundamental transformations in all life processes and organic synthesis. The synthesis of structurally ubiquitous amide motifs is essential in the assembly of numerous important molecules such as peptides, proteins, alkaloids, pharmaceutical agents, polymers, ligands and agrochemicals. A method of SO2F2-mediated direct clickable coupling of carboxylic acids with amines was developed for the synthesis of a broad scope of amides in a simple, mild, highly efficient, robust and practical manner (>110 examples, >90% yields in most cases). The direct click reactions of acids and amines on a gram scale are also demonstrated using an extremely easy work-up and purification process of washing with 1 M aqueous HCl to provide the desired amides in greater than 99% purity and excellent yields.

N, N - disubstituted α, β - unsaturated carboxylic acid amide of (by machine translation)

The present invention is [a], the reaction time is short, suitable for mass-production by gas phase reaction N, N - disubstituted α, β - unsaturated carboxylic acid amide manufacturing method. [Solution] N, N - disubstituted α, β - unsaturated carboxylic acid amide is produced, N, N - disubstituted aldehyde carboxylic amide, in the presence of a catalyst, vapor phase reaction, N, N - disubstituted α, β - unsaturated carboxylic acid amide with. [Drawing] no (by machine translation)

Preparation method of single-functionality or multi-functionality acrylamide type compounds

The present invention relates to the field of new material fine chemicals, particularly to a new mild, efficient and economical preparation process technology of a class of single-functionality or multi-functionality acrylamide type compounds, wherein the materials are important alkene-containing unsaturated compounds, and are increasingly used in radiation polymerization curing materials or medical application materials and other fields.

Translating Thermal Response of Triblock Copolymer Assemblies in Dilute Solution to Macroscopic Gelation and Phase Separation

The thermal response of semi-dilute solutions (5 w/w%) of two amphiphilic thermoresponsive poly(ethylene oxide)-b-poly(N,N-diethylacrylamide)-b-poly(N,N-dibutylacrylamide) (PEO45-PDEAmx-PDBAm12) triblock copolymers, which

MANUFACTURING METHOD OF β-SUBSTITUTED PROPIONIC ACID AMIDE AND N-SUBSTITUTED (METH)ACRYLAMIDE

PROBLEM TO BE SOLVED: To provide a method for industrially manufacturing β-alkoxy propionic acid amide, β-amino propionic acid amide and N-substituted (meth)acryl amide using (meth)acrylic acid ester as starting material at high yield and high purity. SOLUTION: There is provided a method for obtaining N-substituted (meth)acryl amide represented by target compound formula (7) by conducting an amidation reaction with amine using β-substituted propionic acid ester represented by the formula (1) of a product of a Michael addition reaction of (meth)acrylic acid ester and alcohol or amine in presence of a metal complex as a catalyst to obtain β-substituted propionic acid amide represented by the formula (3) and conducting a thermal decomposition reaction of β-substituted propionic acid amide in presence of the metal complex as the catalyst to eliminate alcohol or amine. A-CH2-C(R1)H-C(=O)-OR2 (1), A-CH2-C(R1)H-C(=O)-N(R3)R4 (3), CH2=C(R1)-C(=O)-N(R3)R4 (7) SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT

Preparation method of acrylamide-based compounds

The present invention relates to the field of fine chemical materials, particularly to a new mild, efficient and economical preparation process technology of a class of acrylamide-type compounds, wherein a beta-amine substituted propionamide precursor is subjected to an in-situ amine elimination reaction under the action of a suitable electrophilic reagent so as to prepare the target product.