919217-49-5 Usage
Explanation
The compound is composed of 12 carbon atoms, 12 hydrogen atoms, 4 nitrogen atoms, and 1 oxygen atom.
Explanation
It contains a pyrazolo[3,4-d]pyrimidin-4-one core structure, which is a heterocyclic ring system consisting of both carbon and nitrogen atoms.
Explanation
The central structure of the compound is a fused ring system containing a pyrazole and a pyrimidine ring.
Explanation
The compound has an o-tolyl group (2-methylphenyl) attached to the core structure, which is an aromatic ring with a methyl group at the ortho position.
Explanation
The compound may exhibit biological activities that could be useful in pharmaceutical research and drug development.
Explanation
Due to its potential biological activities, the compound can be further studied for its use in treating various diseases and disorders.
Explanation
More research is needed to fully understand the compound's potential uses, implications, and effectiveness in treating specific diseases and disorders.
Explanation
The solubility of the compound in different solvents is not provided in the given material.
Explanation
The stability of the compound under various conditions is not provided in the given material.
Explanation
The methods for synthesizing the compound are not provided in the given material.
Heterocyclic Compound
Yes
Core Structure
Pyrazolo[3,4-d]pyrimidin-4-one
Substituent
1-o-tolyl
Potential Biological Activities
Yes
Applications
Pharmaceutical Research and Drug Development
Further Research
Required
Solubility
Not mentioned in the material
Stability
Not mentioned in the material
Syntheses
Not mentioned in the material
Check Digit Verification of cas no
The CAS Registry Mumber 919217-49-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,1,9,2,1 and 7 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 919217-49:
(8*9)+(7*1)+(6*9)+(5*2)+(4*1)+(3*7)+(2*4)+(1*9)=185
185 % 10 = 5
So 919217-49-5 is a valid CAS Registry Number.
919217-49-5Relevant academic research and scientific papers
Identification of novel GLUT inhibitors
Siebeneicher, Holger,Bauser, Marcus,Buchmann, Bernd,Heisler, Iring,Müller, Thomas,Neuhaus, Roland,Rehwinkel, Hartmut,Telser, Joachim,Zorn, Ludwig
, p. 1732 - 1737 (2016/07/27)
The compound class of 1H-pyrazolo[3,4-d]pyrimidines was identified using HTS as very potent inhibitors of facilitated glucose transporter 1 (GLUT1). Extensive structure–activity relationship studies (SAR) of each ring system of the molecular framework was established revealing essential structural motives (i.e., ortho-methoxy substituted benzene, piperazine and pyrimidine). The selectivity against GLUT2 was excellent and initial in vitro and in vivo pharmacokinetic (PK) studies are encouraging.
Novel pyrazolopyrimidine derivatives as GSK-3 inhibitors
Peat, Andrew J.,Boucheron, Joyce A.,Dickerson, Scott H.,Garrido, Dulce,Mills, Wendy,Peckham, Jennifer,Preugschat, Frank,Smalley, Terrence,Schweiker, Stephanie L.,Wilson, Jayme R.,Wang, Tony Y.,Zhou, Huiqiang Q.,Thomson, Stephen A.
, p. 2121 - 2125 (2007/10/03)
A series of [1-aryl-1H-pyrazolo[3,4-d]pyrimidin-4-yl]arylhydrazones were discovered as novel inhibitors glycogen synthase kinase-3 (GSK-3). Based on initial modeling a detailed SAR was constructed. Modification of the interior binding aryl ring (Ar1) determined this to be a tight binding region with little room for modification. As predicted from the model, a large variety of modifications could be incorporated into the hydrazone aryl ring. This work led to GSK-3 inhibitors in the low nano-molar range.
