919283-75-3

Upstream product

• 120-83-2 2,4-dichlorophenol 
• 57017-95-5 methyl 3-chloro-4-hydroxyphenylacetate 
• 33697-81-3 (3-chloro-4-hydroxy-phenyl)-acetic acid 
• 1199-28-6 2-(2,4-dichlorophenoxy)ethylamine 
• 870194-52-8 (3-chloro-4-formylphenyl)acetic acid methyl ester 
• 1047641-65-5 4-methyl-3-oxo-pentanoic acid [2-(2,4-dichloro-phenoxy)-ethyl]-amide 
• 496856-44-1 methyl 2-(3-chloro-4-(triuoromethylsulfonyloxy)phenyl)acetate 
• 870194-65-3 tert-butyl (2-(2,4-dichlorophenoxy)ethyl)carbamate 
• 870194-53-9 [3-chloro-4-(hydroxyimino-methyl)-phenyl]-acetic acid methyl ester 
• 496856-45-2 (3-chloro-4-cyanophenyl)acetic acid methyl ester 

Relevant academic research and scientific papers

3,4,5-Trisubstituted isoxazoles as novel PPARδ agonists: Part 1

We report the identification of a novel series of trisubstituted isoxazoles as PPAR activators from a high-throughput screen. A series of structural optimizations led to improved efficacy and excellent functional receptor selectivity for PPARδ. The isoxazoles represent a series of agonists which display a scaffold that lies outside the typical PPAR agonist motif.