91944-43-3

Upstream product

• 120-26-3 2-(3,4-dimethoxyphenyl)-1-methylethylamine 
• 91944-39-7 3-phenoxy>-1,2-epoxypropane 
• 91944-36-4 2-[4-(2,2-Dimethyl-[1,3]dioxolan-4-ylmethoxy)-phenyl]-5-thiophen-2-yl-1H-imidazole 
• 584-08-7 potassium carbonate 
• 98-59-9 p-toluenesulfonyl chloride 
• 70552-22-6 2-(p-hydroxyphenyl)-4-(2-thienyl)imidazole 
• 126007-93-0 Methanesulfonic acid 2-hydroxy-3-[4-(5-thiophen-2-yl-1H-imidazol-2-yl)-phenoxy]-propyl ester 
• 91944-37-5 3-[4-(5-Thiophen-2-yl-1H-imidazol-2-yl)-phenoxy]-propane-1,2-diol 

Relevant academic research and scientific papers

BETA-BLOCKING SUBSTITUTED IMIDAZOLES

Novel substituted imidazoles and methods for their preparation are disclosed. These imidazoles, and their salts, exhibit pharmacological activity which includes antihypertensive activity and β-adrenergic blocking activity.

BETA-ADRENERGIC BLOCKING IMIDAZOLYLPHENOXY PROPANOLAMINES

Substituted imidazoles and methods for their preparation are disclosed. These imidazoles, and their salts, exhibit pharmacological activity which includes antihypertensive activity and β-adrenergic blocking activity. STR1

3-AMINO-2-HYDROXYPROPOXYARYL IMIDAZOLE DERIVATIVES

Novel substituted imidazoles of the formula STR1 and methods for their preparation are disclosed. These imidazoles, and their salts, exhibit pharmacological activity which includes antihypertensive activity and β-adrenergic blocking activity.

β1-Selective adrenoceptor antagonists: Examples of the 2-[4-[3-(substituted-amino)-2-hydroxypropoxy]phenyl]imidazole class

A series of 2-[4-[3-(substituted-amino)-2-hydroxypropoxy]phenyl]imidazoles is described. The compounds were investigated in vitro for β-adrenoceptor antagonism, and several examples were found to be selective for the β1-adrenoceptor. The structure-activity relationship exhibited by this series of compounds is discussed. (S)-2-[p-[3-[[2-(3,4-dimethoxyphenyl)ethyl]amino]-2-hydroxypropoxy]phenyl] -4-(2-thienyl)imidazole [(S)-13] was over 100 times more selective than atenolol for the β1-adrenergic receptor and has been selected for in-depth studies.