91968-53-5Relevant academic research and scientific papers
Scandium trifluoromethanesulfonate as a recyclable catalyst for efficient methoxymethylation of alcohols
Karimi, Babak,Ma'mani, Leyla
, p. 6051 - 6053 (2003)
Scandium triflate [Sc(OTf)3] has been found to be a recyclable catalyst for mild highly efficient methoxymethylation of a variety of alcohols using formaldehyde dimethyl acetal (FDMA).
A chloromethyl methyl ether and its armor oxygen methyl protection method for the synthesis of the compounds of
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Paragraph 0065; 0066; 0067; 0068, (2016/10/10)
The invention provides chloromethyl methyl ether and a synthesis method of a compound protected by methoxymethyl thereof. The chloromethyl methyl ether (MOMCl) is a common protective reagent in organic synthesis. Commonly used synthesis methods are tedious in operation and long in reaction time. The synthesis method provided by the invention comprises: with trifluoromethane sulfonic acid or perchloric acid as a catalyst, reacting acyl chloride with dimethoxymethane to synthesize the chloromethyl methyl ether. The chloromethyl methyl ether produced in situ can directly act with a hydroxyl compound and organic alkali dissolved in an organic solvent to generate a product with hydroxyl protected by MOM. The method has the advantages of high reaction speed and simple reaction operation. Therefore, the method can be applicable to the production and application of a continuous flow reactor.
