91994-60-4

Upstream product

• 100-42-5 styrene 
• 407-25-0 trifluoroacetic anhydride 
• 96-09-3 styrene oxide 
• 354-38-1 2,2,2-trifluoroacetamide 
• 1337984-76-5 1-(2,2,2-trifluoroacetylimino)pyridinium ylide 
• 5468-37-1 2-aminoacetophenone hydrochloride 
• 91994-49-9 2,2,2-trifluoro-N-(2-oxo-2-phenylethyl)acetamide 

Downstream Products

• 7568-93-6 2-Amino-1-phenylethanol 

Relevant academic research and scientific papers

Pyrazolone-based nitrido complexes: Synthesis and nitrogen transfer to alkenes

The first examples of alkylpyrazolone based nitridomanganese(v) complexes are here reported. Styrene was used as a test substrate to study the complex's ability to transfer nitrogen in stoichiometric reactions. Preliminary trials yielded 75 to 91% of N-(2

Aminohydroxylation of olefins with iminopyridinium ylides by dual Ir photocatalysis and Sc(OTf)3catalysis

We have developed a new strategy for catalytic aminohydroxylation of olefins with an N-protected iminopyridinium ylide as the amine source. Iminopyridinium ylides N-protected with TFAc (trifluoroacetyl), Boc (tert-butoxycarbonyl), Troc (2,2,2-trichloroethoxycarbonyl), and Alloc (allyloxycarbonyl) groups serve as N-centered radical precursors when combined with fac-[Ir(ppy)3] photocatalysis and Sc(OTf)3catalysis. The dual Ir photoredox/Sc(OTf)3catalysis proves to be effective for aminohydroxylation of olefins under mild reaction conditions to provide 2-aminoalcohol derivatives bearing a primary amino group.

Regioselective opening of epoxides to β-amido alcohols under solid-liquid PTC conditions

A study on the ring opening of a number of epoxides 1 with trifluoroacetamide (2) under solid-liquid phase transfer catalysis (SL-PTC) conditions has been performed. The reaction is completely regioselective affording β-amido alcohols 3 deriving from the attack of the nucleophile to the less substituted carbon atom of the oxirane ring.

Synthesis and structure of Novel Mn(III) and Mn(V) complexes: Development of a new, mild method for forming Mn≡N bonds

Novel reagents for olefin amination - A new class of manganese(V) nitrides containing Schiff bases as ligands was prepared from the corresponding Mn(III) complexes following a new mild oxidative procedure. Structures of examples of both the Mn(III) starti

Baker's Yeast Reduction of α-(Acylamino)acetophenones and Lipase Catalyzed Resolution of 2-Acylamino-1-arylethanols

Enzymatic reduction of α-acylaminoacetophenones with fermenting baker's yeast afforded optically active (R)-2-acylamino-1-arylethanols.Furthermore, lipase-catalyzed resolution of the 2-acylamino-1-arylethanols using vinyl acetate as an acyl donor resulted in the formation of (S)-1-acetoxy-2-acylamino-1-arylethanols and (R)-2-acylamino-1-arylethanols.

Friedel-Crafts Acylation with N-(Trifluoroacetyl)-α-amino Acid Chlorides. Application to the Preparation of β-Arylalkylamines and 3-Substituted 1,2,3,4-Tetrahydroisoquinolines

Several N-(trifluoroacetyl)-α-amino acid chlorides have been reacted with benzene, anisole, and veratrole in the presence of AlCl3 or SnCl4 to produce the corresponding aromatic ketones in fair to high yields.The products are reductible under neutral or acidic conditions to the corresponding N-(trifluoroacetyl)-β-hydroxy-β-arylakylamines or N-(trifluoroacetyl)-β-arylalkylamines.The latter can be readily detrifluoroacetylated by mild basic hydrolysis and thence converted to the corresponding 3-substituted 1,2,3,4-tetrahydroisoquinolines by condensation with formaldehyde.