91994-49-9

Basic information

• Product Name: Acetamide, 2,2,2-trifluoro-N-(2-oxo-2-phenylethyl)-
• CAS NO: 91994-49-9
• Molecular Formula: C10H8F3NO2
• Molecular Weight: 231.174
• Mol File: 91994-49-9.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: Acetamide, 2,2,2-trifluoro-N-(2-oxo-2-phenylethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, 2,2,2-trifluoro-N-(2-oxo-2-phenylethyl)-(91994-49-9)
• EPA Substance Registry System: Acetamide, 2,2,2-trifluoro-N-(2-oxo-2-phenylethyl)-(91994-49-9)

Safety Data

• Hazardous Substances Data: 91994-49-9(Hazardous Substances Data)

Upstream product

• 383-69-7 (2,2,2-trifluoro-acetylamino)-acetyl chloride 
• 71-43-2 benzene 
• 13735-81-4 1-styrenyloxytrimethylsilane 
• 407-25-0 trifluoroacetic anhydride 
• 76-05-1 trifluoroacetic acid 
• 1680-44-0 4-phenyl-1H-1,2,3-triazole 
• 100-42-5 styrene 
• 102921-26-6 (1,2-dibromoethyl)benzene 
• 29847-04-9 1-(1-azido-2-bromoethyl)benzene 
• 16717-64-9 1-azidostyrene 
• 7654-06-0 3-phenyl-2H-azirine 
• 2206-94-2 1-acetoxy-1-phenylethene 
• 3397-30-6 2-(2,2,2-trifluoroacetamido)acetic acid succinimidyl ester 
• 354-38-1 2,2,2-trifluoroacetamide 

Downstream Products

• 68579-60-2 2-(methylamino)-1-phenylethanol 
• 57052-65-0 2,2,2-trifluoro-N-methyl-N-(2-oxo-2-phenylethyl)acetamide 
• 7568-93-6 2-Amino-1-phenylethanol 
• 91994-60-4 N-(2-hydroxy-2-phenylethyl)-2,2,2-trifluoroacetylamide 
• 5468-37-1 2-aminoacetophenone hydrochloride 
• 458-85-5 2,2,2-trifluoro-N-(2-phenylethyl)acetamide 

Relevant articles and documents

Access to Fluoroalkylated Azoles and 2-Acylaminoketones via Fluorinated Anhydride-Mediated Cleavage of NH-1,2,3-Triazoles

NH-1,2,3-Triazoles undergo a ring cleavage in reactions with fluorinated acid anhydrides (trifluoroacetic, difluoroacetic, chlorodifluoroacetic, and pentafluoropropionic anhydrides) by nitrogen acylation and acid-mediated triazole ring opening. Structurally diverse fluoroalkylated oxazoles were prepared from 4,5-disubstituted-1,2,3-triazoles. Efficient synthesis of 2-acylaminoketones was achieved from 4-substituted 1,2,3-triazoles. Finally, easy access to fluoroalkylated imidazoles and 1,2,4-triazines was developed by a one-pot two-step route from NH-triazoles, fluorinated anhydrides, and amines or hydrazine.

Visible-Light-Mediated Amination of π-Nucleophiles with N-Aminopyridinium Salts

N-Aminopyridinium salts generate nitrogen-centered radicals by means of photoredox catalysis. Herein, we report that they can be trapped by enol equivalents to give α-amino carbonyl compounds in excellent yields. The broad synthetic utility of this method is demonstrated by functionalization of ketones, aldehydes, esters enol equivalents, vinyl ethers, and 1,3-diketones without the need for prior conversion to enol derivatives. The developed method is easily scalable, offers broad substrate scope, high chemoselectivity.

Synthesis of chiral TFA-protected α-amino aryl-ketone derivatives with friedel-crafts acylation of α-amino acid n-hydroxysuccinimide ester

Chiral N-protected α-amino aryl-ketones are one of the useful precursors used in the synthesis of various biologically active compounds and can be constructed via Friedel-Crafts acylation of N-protected α-amino acids. One of the drawbacks of this reaction