920145-51-3

Basic information

• Product Name: 4-(5-methylbenzo[d]oxazol-2-yl)benzonitrile
• Synonyms: 4-(5-methylbenzo[d]oxazol-2-yl)benzonitrile
• CAS NO: 920145-51-3
• Molecular Weight: 234.257
• Mol File: 920145-51-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 4-(5-methylbenzo[d]oxazol-2-yl)benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(5-methylbenzo[d]oxazol-2-yl)benzonitrile(920145-51-3)
• EPA Substance Registry System: 4-(5-methylbenzo[d]oxazol-2-yl)benzonitrile(920145-51-3)

Safety Data

• Hazardous Substances Data: 920145-51-3(Hazardous Substances Data)

Upstream product

• 95-84-1 3-amino-4-hydroxytoluene 
• 3058-39-7 4-iodobenzonitrile 
• 350015-18-8 4-(3-oxo-3-phenylprop-1-yn-1-yl)benzonitrile 
• 926013-72-1 4-(3-hydroxy-3-phenylprop-1-yn-1-yl)benzonitrile 
• 105-07-7 4-cyanobenzaldehyde 
• 623-03-0 4-Cyanochlorobenzene 
• 10531-78-9 5-methyl-1,3-benzoxazole 

Relevant articles and documents

Synthesis of benzoxazoles via the copper-catalyzed hydroamination of alkynones with 2-aminophenols

We describe herein the synthetic method to benzoxazole derivatives via the copper-catalyzed hydroamination of alkynones with 2-aminophenols. The method produced a wide variety of functionalized benzoxazole derivatives in good yields. Preliminary mechanistic experiments revealed that the reaction would proceed through the copper-catalyzed hydroamination of alkynones and the sequential intramolecular cyclization of β-iminoketones/elimination of acetophenone promoted by the copper catalyst.

Palladium(II) Immobilized Onto the Glucose Functionalized Magnetic Nanoparticle as a New and Efficient Catalyst for the One-pot Synthesis of Benzoxazoles

Palladium(II) have been immobilized into the nano magnetic Fe3O4 which was functionalized with glucose in order to achieve a one-pot synthesis of 2-substituted benzoxazole derivatives with high yields in the diverse range of organic solvents. The nano catalyst is highly dispersive in polar solvents and can be easily recovered and reused for 6 runs without significant loss of its activity. Finally, the catalyst was fully characterized by FT-IR, TGA, CHN, SEM, EDX and atomic absorption spectroscopy.

A one-pot, two-step microwave-assisted synthesis of highly functionalized benzoxazoles using solid-supported reagents (SSRs)

A one-pot, two-step protocol for the microwave-assisted solid-phase synthesis of substituted benzoxazoles has been developed starting from different polymer-bound esters we previously designed as solid-supported reagents (SSRs) for the acylation of amines, alcohols and phenols. The combination of a parallel synthesizer and a microwave reactor allowed to quickly prepare a collection of substituted benzoxaxoles in high purity and satisfactory yields. This protocol is amenable for automation and could be used for the preparation of combinatorial libraries in drug discovery programs.