350015-18-8

Basic information

• Product Name: Benzonitrile, 4-(3-oxo-3-phenyl-1-propynyl)-
• CAS NO: 350015-18-8
• Molecular Formula: C16H9NO
• Molecular Weight: 231.254
• Mol File: 350015-18-8.mol
• Article Data: 19

Chemical Properties

• CAS DataBase Reference: Benzonitrile, 4-(3-oxo-3-phenyl-1-propynyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzonitrile, 4-(3-oxo-3-phenyl-1-propynyl)-(350015-18-8)
• EPA Substance Registry System: Benzonitrile, 4-(3-oxo-3-phenyl-1-propynyl)-(350015-18-8)

Safety Data

• Hazardous Substances Data: 350015-18-8(Hazardous Substances Data)

Upstream product

• 3032-92-6 4-cyanophenylacetylene 
• 98-88-4 benzoyl chloride 
• 64-18-6 formic acid 
• 369-57-3 benzenediazonium tetrafluoroborate 
• 100-52-7 benzaldehyde 
• 926013-72-1 4-(3-hydroxy-3-phenylprop-1-yn-1-yl)benzonitrile 
• 3058-39-7 4-iodobenzonitrile 
• 4187-87-5 1-Phenyl-2-propyn-1-ol 
• 98-86-2 acetophenone 
• 1074-12-0 phenylglyoxal hydrate 
• 75867-40-2 4-[2-(trimethylsilyl)ethynyl]benzonitrile 
• 201230-82-2 carbon monoxide 
• 59-88-1 phenylhydrazine hydrochloride 
• 134-81-6 benzil 

Downstream Products

• 1198463-89-6 (Z)-3-(4-cyanophenyl)-1-phenyl-3-(phenylamino)prop-2-en-1-one 
• 920145-51-3 4-(5-methylbenzo[d]oxazol-2-yl)benzonitrile 
• 72758-75-9 (E)-4-(3-oxo-3-phenylprop-1-en-1-yl)benzonitrile 
• 36803-56-2 4-(2-(4-methoxyphenyl)-2-oxoacetyl)benzonitrile 
• 29822-79-5 4-(2-phenylethynyl)benzonitrile 
• 1179538-75-0 C₂₂H₁₄ClIN₂O 

Relevant articles and documents

Sc(OTf)3-catalyzed [3 + 2]-cycloaddition of nitrones with ynones

An efficient approach to access functionalized (2,3-dihydroisoxazol-4-yl) ketones has been developed by reacting nitrones 4 with ynones 7 or terminal ynones 10 in a one-pot fashion. The reaction went through a formal Sc(OTf)3-catalyzed [3 + 2]-cycloaddition process to generate a number of functionalized (2,3-dihydroisoxazol-4-yl) ketones 11aa-11aw, 11ba-11la and 12aa-12ae in moderate to good yields. This journal is

Ynonylation of Acyl Radicals by Electroinduced Homolysis of 4-Acyl-1,4-dihydropyridines

Herein we report the conversion of 4-Acyl-1,4-dihydropyridines (DHPs) into ynones under electrochemical conditions. The reaction proceeds via the homolysis of acyl-DHP under electron activation. The resulting acyl radicals react with hypervalent iodine(III) reagents to form the target ynones or ynamides in acceptable yields. This mild reaction condition allows wider functionality tolerance that includes halides, carboxylates, or alkenes. The synthetic utility of this methodology is further demonstrated by the late-stage modification of complex molecules.

Selective Insertion of Alkynes into C-C σ Bonds of Indolin-2-ones: Transition-Metal-Free Ring Expansion Reactions to Seven-Membered-Ring Benzolactams or Chromone Derivatives

An unprecedented ring expansion reaction of indolin-2-ones with alkynyl ketones under transition-metal-free conditions has been developed. Base-promoted selective cleavage of a C-C σ bond of the amide is the key in this process, which provides a straightf