92016-94-9

Usage

Uses

Used in Pharmaceutical Industry:
2-(4-Methoxy-phenyl)-cyclopropanecarboxylic acid is used as an antitumor agent for its potential effects on cancer cells, making it a candidate for further research and development in oncology.
Used in Coordination Chemistry:
2-(4-Methoxy-phenyl)-cyclopropanecarboxylic acid is used as a ligand, which may contribute to the development of new coordination compounds with potential applications in various fields.
Used in Organic Synthesis:
2-(4-Methoxy-phenyl)-cyclopropanecarboxylic acid is used in the synthesis of various organic compounds, leveraging its unique chemical structure to create new molecules with potential applications in different industries.

Upstream product

• 948551-64-2 methyl trans-2-(4-methoxyphenyl)cyclopropanecarboxylate 
• 98017-60-8 2-(4-methoxyphenyl)cyclopropanecarboxylic acid ethyl ester 
• 123-11-5 4-methoxy-benzaldehyde 
• 3901-07-3 3-(4-methoxy-phenyl)acrylic acid methyl ester 
• 51507-22-3 (Z)-ethyl 3-(4-methoxyphenyl)acrylate 
• 301861-18-7 trans-2-(4-methoxyphenyl)cyclopropane-1-carbonitrile 

Downstream Products

• 1226460-14-5 N'-isonicotinoyl-2-(4-methoxyphenyl)cyclopropanecarboxylhydrazide 
• 1226460-20-3 2-(4-methoxyphenyl)-N'-(phthalazin-1-yl)cyclopropanecarbohydrazide 
• 1226460-26-9 3-[2-(4-methoxyphenyl)cyclopropyl]-[1,2,4]triazolo[3,4-a]phthalazine 
• 1356599-19-3 (1R,2S)-2-{4-[(4-{[(2Z)-2-(4-cyanophenyl)-2-(methoxyimino)ethyl]oxy}benzyl)oxy]phenyl}cyclopropanecarboxylic acid 
• 1356600-36-6 (1R,2S)-2-(4-hydroxyphenyl)cyclopropanecarboxylic acid 
• 1356600-37-7 benzyl (1R,2S)-2-(4-hydroxyphenyl)cyclopropanecarboxylate 
• 1314323-95-9 (1R,2S)-tert-butyl 2-(4-methoxyphenyl)cyclopropylcarbamate 
• 220349-83-7 (1R,2S)-2-(4-methoxyphenyl)cyclopropanamine 

Relevant academic research and scientific papers

KDM1A INHIBITORS FOR THE TREATMENT OF DISEASE

Disclosed herein are new compounds and compositions and their application as pharmaceuticals for the treatment of diseases. Methods of inhibition of KDMIA, methods of increasing gamma globin gene expression, and methods to induce differentiation of cancer cells in a human or animal subject are also provided for the treatment of diseases such as acute myelogenous leukemia.

METHODS OF TREATMENT USING ARYLCYCLOPROPYLAMINE COMPOUNDS

Described herein are methods of treating Parkinson's disease using arylcyclopropylamine compounds.

AGONISTS OF GPR40

The present invention relates to compounds that have the ability to modulate the activity of GPR40 and are there-fore useful in the treatment of GPR40 related disorders. In addition the invention relates to the compounds, methods for their preparation, pharmaceutical compositions containing the compounds and the uses of these compounds in the treatment of certain disorders related to GPR40 activity.

Synthesis and anticancer activity evaluation of 2(4-alkoxyphenyl)cyclopropyl hydrazides and triazolo phthalazines

A series of new 2(4-alkoxyphenyl)cyclopropyl hydrazide- and triazolo-derivatives were synthesized starting from 4-hydroxycinnamic acid (1) in a clean, mild, efficient and straightforward synthetic protocol. These compounds consisting of different alkoxy substitution, phenylcyclopropyl backbone and different heterocyclic groups were evaluated for in vitro anticancer activity against 4 cell lines displaying certain levels of resistance to pro-apoptotic stimuli and 2 cell lines sensitive to pro-apoptotic compounds. Compounds 7f and 8e were most active and displaying moderate in vitro cytostatic effect through different mechanisms. Significantly, chemically modified derivatives could be obtained in order to develop novel types of compounds aiming to combat apoptosis-resistant cancers, for example, those cancers associated with dismal prognoses.

Cinnamide and hydrocinnamide derivatives with kinase inhibitory activity

The present invention provides novel cinnamide compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases.

Enantioselective synthesis of chiral cyclopropane compounds through microbial transformations of trans-2-arylcyclopropanecarbonitriles

Enantioselective biotransformations of racemic trans-2-arylcyclopropanecarbonitriles catalyzed by Rhodococcus sp. AJ270 cells proceeded efficiently to give good to excellent optical yields of (-)-(1R,2R)-2-arylcyclopropanecarboxamides and (+)-(1S,2S)-2-arylcyclopropanecarboxylic acids, which were converted into optically active cyclopropylmethylamine and cyclopropylamine derivatives upon reduction and the Curtius rearrangement. (C) 2000 Elsevier Science Ltd.