920502-65-4Relevant academic research and scientific papers
γ-Lactones α,β- and β,γ-fused to carbocycles as novel antiproliferative drugs
Leon, Leticia G.,Machin, Ruben P.,Rodriguez, Carmen M.,Ravelo, Jose L.,Martin, Victor S.,Padron, Jose M.
scheme or table, p. 5171 - 5173 (2009/05/07)
A set of γ-lactones α,β-fused and β,γ-fused to carbocycles have been synthesized and evaluated for their in vitro antiproliferative activities using the human cancer cell lines SW1573 (lung), T-47D (breast) and WiDr (colon). The compounds are obtained by
γ-Lactones as templates in ring-closing metathesis: Enantioselective synthesis of medium sized carbocycles fused to butyrolactones
Ravelo, José Luis,Rodríguez, Carmen Ma,Martín, Víctor S.
, p. 5326 - 5335 (2007/10/03)
A methodology for accessing enantiomerically enriched carbocyclic systems fused to γ-lactones is described. Key steps are the stereoselective synthesis of highly substituted γ-lactones and ring-closing metathesis of the suitable ramifications. The process permits the choice of stereochemistry, regioselectivity and ring size of the fused compounds.
