92081-75-9Relevant academic research and scientific papers
Synthesis and crystallographic characterization of thiazoIe-2-dithiocarboxylate methyl ester complexes of chromium
Raubenheimer, Hclgard G.,Marais, Eugene K.,Cronje, Stephanie,Esterhuysen, Catharine,Kruger, Gert J.
, p. 3016 - 3021 (2000)
Co-ordination of 4-methylthiazole-2-dithiocarboxylate methyl ester, I, or benzothiazole-2-dithiocarboxylate methyl ester, II, to [Cr(CO)5(THF)]. [W(CO)5(THF)] or [Fe(CO)4(THF)] afforded the new complexes [lI(CO)4{S=C(SCH3)C=yC(CH3)=CHS}] (M = Cr 1 or W 2), [Cr(CO)4{S=C(SCH})C=ffC6H4a-o}] 3, [Fe(CO)3{S=C(SCH3)C=yC(CH3)=CHS}] 4 and [Fe(CO)a{S=C(SCH3)0=ISC6H4S-o}] 5. Single crystal X-ray structure determinations of 1 and 5 revealed co-ordination of the bidentate ligands through the exocyclic thione sulfur and endocyclic imine nitrogen atoms by five-membered chelate ring formation. Compound 5 has a unique trigonal bipyramidal configuration. The Royal Society of Chemistry 2000.
Novel synthesis of heterocyclic aryl amidines
Tommasi, Ruben A.,Macchia, William M.,Parker, David T.
, p. 5947 - 5950 (2007/10/03)
We have developed a novel amidine synthesis that allows the preparation of heterocyclic amidines that were previously unknown and difficult to prepare by published methods. The route involves the lithiation of heterocycles by the action of n-BuLi followed
Dithiocarboxylic Acids, Dithiocarboxylic Esters, or Thiocarboxylic Amides by Reaction of Methylene-active Chloromethyl Compounds with Sulfur
Thiel, W.,Mayer, R.
, p. 243 - 262 (2007/10/02)
With a mixture of sulfur and amine in DMF at room temperature halomethyl compounds (1,5-10) can be oxidized to give thiocarboxylic acids (2,11-16) and their derivatives (3,4,17-35).We studied this reaction in detail especially with chloroacetic derivatives (11-15) or chloromethyl heterocycles (16) formally derived from chloroacetic acid.The resulting thiooxalic acid derivatives (11-27) represent activated acids and very useful C2-synthons, especially for the synthesis of heterocycles.Oxidation in the presence of triethylamine leads to dithiocarboxylates (11-16) which can be alkylated to dithioesters (17-27) in high yields.As a rule, with different primary and secondary amines instead of tertiary amines these dithiocarboxylates or dithiocarboxylic esters can be transformed already at low temperatures to thioamides (28-35).
