92083-19-7Relevant academic research and scientific papers
Solvent-free, microwave-assisted N-arylation of indolines by using low palladium catalyst loadings
Basolo, Luca,Bernasconi, Alice,Borsini, Elena,Broggini, Gianluigi,Beccalli, Egle M.
experimental part, p. 1637 - 1642 (2012/03/10)
Indoline-based compounds are abundant in nature, and the indoline skeleton is an often-encountered scaffold in a range of biologically active alkaloids, pharmaceutically active compounds, and functional molecules (e.g., sensitizers for solar cells). The wide range of uses warrants further interest in the structural modification of this class of compounds. A series of substituted N-aryl indolines is prepared by a solvent-free, palladium-catalyzed procedure. The procedure requires only low loadings of catalyst, uses microwave irradiation, and starts from commercially available substrates. The method proceeds in good yields and in short reaction times with aryl bromides, chlorides, and iodides, also on 2-substituted indolines. The combination of solvent-free methods with microwave heating will further increase in importance in the search for more environmentally acceptable synthesis methods. Copyright
Copper + nickel-in-charcoal (Cu-Ni/C): A bimetallic, heterogeneous catalyst for cross-couplings
Lipshutz, Bruce H.,Nihan, Danielle M.,Vinogradova, Ekaterina,Taft, Benjamin R.,Boskovic, Zarko V.
supporting information; experimental part, p. 4279 - 4282 (2009/05/30)
(Chemical Equation Presented) A new heterogeneous catalyst composed of copper and nickel oxide particles supported within charcoal has been developed. It catalyzes cross-couplings that traditionally use palladium, nickel, or copper, including Suzuki-Miyaura reactions, Buchwald-Hartwig aminations, vinylalane alkylations, etherifications of aryl halides, aryl halide reductions, asymmetric conjugate reductions of activated olefins, and azide-alkyne "click" reactions.
Substituent-dependent photoinduced intramolecular charge transfer in N-aryl-substituted trans-4-aminostilbenes
Yang, Jye-Shane,Liau, Kang-Ling,Wang, Chin-Min,Hwang, Chung-Yu
, p. 12325 - 12335 (2007/10/03)
The photochemical behavior of trans-4-(N-arylamino)stilbene (1, aryl = 4-substituted phenyl) in solvents more polar than THF is strongly dependent on the substituent in the N-aryl group. This is attributed to the formation of a twisted intramolecular char
1-(Aminoalkylphenyl and aminoalkylbenzyl)-indoles and indolines and analgesic method of use thereof
-
, (2008/06/13)
The invention relates to 1-(aminoalkylphenyl and aminoalkylbenzyl)indoles and indolines of the formula: STR1 where R1 and R2 are the same or different and are hydrogen, lower alkyl, cycloalkyl and acyl of the formula STR2 where Rsub
