92099-56-4

Upstream product

• 507-20-0 tertiary butyl chloride 
• 587-04-2 m-Chlorobenzaldehyde 
• 630-19-3 pivalaldehyde 
• 541-73-1 1,3-Dichlorobenzene 
• 108-37-2 1-bromo-3-chlorobenzene 
• 3282-30-2 pivaloyl chloride 
• 36229-42-2 (3-chlorophenyl)magnesium bromide 

Downstream Products

• 120136-22-3 3-Nitro-benzenesulfonic acid 1-(3-chloro-phenyl)-2,2-dimethyl-propyl ester 
• 120136-10-9 1-tert-Butyl-1-(3'-chlorophenyl)methyl tosylate 
• 205678-77-9 1-Chlor-2,2-dimethyl-1-(3-chlor-phenyl)-propan 

Relevant academic research and scientific papers

Iron-Catalyzed Asymmetric Decarboxylative Azidation

The first iron-catalyzed asymmetric azidation of benzylic peresters has been reported with trimethylsilyl azide (TMSN3) as the azido source. Hydrocarbon radicals that lack of strong interactions were capable to be enantioselectively azidated. The reaction features good functional group tolerance, high yields, and mild conditions. The chiral benzylic azides can further be used in click reaction, phosphoramidation, and reductive amination, which demonstrate the synthetic values of this reaction.

Naphthalene-catalysed lithiation of functionalized chloroarenes: Regioselective preparation and reactivity of functionalized lithioarenes

The lithiation of different functionalized chloroarenes (dichlorobenzenes 1 and 3, mono and dichlorophenols 9 and 14, and chloropivalanilides 18) in the presence of a catalytic amount of naphthalene leads to the corresponding functionalized lithioarenes, which react with electrophiles to give the expected polyfunctionalized aromatic molecules 2, 4, 10, 19, 21, 22 and 24 in a regioselective manner. In the case of starting from chlorinated phenols or anilides a deprotonation of the functional group is carried out prior to the lithiation process; only for 2-chloropivalanilide 18o a coupling reaction leading to 2-n-butylpivalanilide is observed when an excess of n-butyllithium is used in the deprotonation step.