921-62-0

Basic information

• Product Name: 6-PHOSPHOGLUCONIC ACID BARIUM SALT
• Synonyms: 6-phosphogluconate;D-gluconic acid 6-(dihydrogen phosphate);6-PHOSPHOGLUCONIC ACID BARIUM GRADE VI;6-pg-ba;(2S,3S,4R,5R)-2,3,4,5-tetrahydroxy-6-phosphonooxy-hexanoic acid;6-PHOSPHOGLUCONATE BARIUM SALT HYDRATE: 70%;D-Gluconic acid-6-phosphate;6-PHOSPHOGLUCONIC ACID BARIUM SALT WHITE POWDER
• CAS NO: 921-62-0
• Molecular Formula: C₆H₁₃O₁₀P
• Molecular Weight: 276.135181
• EINECS: 213-069-9
• Product Categories: Ba (Barium) Compounds;Classes of Metal Compounds;Typical Metal Compounds
• Mol File: 921-62-0.mol

Chemical Properties

• Boiling Point: 774.8 °C at 760 mmHg
• Flash Point: 422.4 °C
• Appearance: white/powder
• Density: 1.983 g/cm³
• Storage Temp.: 2-8°C
• PKA: 1.84±0.10(Predicted)
• BRN: 1729373
• CAS DataBase Reference: 6-PHOSPHOGLUCONIC ACID BARIUM SALT(CAS DataBase Reference)
• NIST Chemistry Reference: 6-PHOSPHOGLUCONIC ACID BARIUM SALT(921-62-0)
• EPA Substance Registry System: 6-PHOSPHOGLUCONIC ACID BARIUM SALT(921-62-0)

Safety Data

• Hazard Codes: Xn
• Statements: 20/22
• Safety Statements: 28
• RIDADR: UN 1564 6.1/PG 3
• WGK Germany: 3
• F: 3-10-21
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 921-62-0(Hazardous Substances Data)

Usage

Uses

Used in Biochemical Research:
6-Phosphogluconic acid barium salt is used as a biochemical research tool for studying the biochemistry of certain organisms and enzymes. It aids in understanding the metabolic pathways and enzymatic reactions involved in the pentose phosphate pathway.
Used in the Study of Coxiella burnetti:
In a specific study, 6-Phosphogluconic acid barium salt was utilized to assess the biochemistry of Coxiella burnetti, a bacterium that causes Q fever in humans. This application helps researchers gain insights into the bacterium's metabolic processes and potential therapeutic targets.
Used in Investigating Enzymatic Transfer of Hydrogen:
6-Phosphogluconic acid barium salt has also been employed in a study to investigate the enzymatic transfer of hydrogen. This application is crucial for understanding the mechanisms of hydrogen transfer in various biochemical reactions, which can be significant in the development of new drugs and therapies.

InChI:InChI=1/2C6H13O10P.3Ba/c2*7-2(1-16-17(13,14)15)3(8)4(9)5(10)6(11)12;;;/h2*2-5,7-10H,1H2,(H,11,12)(H2,13,14,15);;;/q;;3*+2/p-6/t2*2-,3-,4+,5-;;;/m11.../s1

Upstream product

• 26368-31-0 6-phosphoglucono-δ-lactone 
• 299-31-0 α-D-glucose 6-phosphate 
• 57-50-1 Sucrose 
• 57-48-7 D-Fructose 
• 299-31-0 β-D-glucose 6-phosphate 
• 299-31-0 glucose-6-phosphate 
• 56-73-5 D-glucose 6-phosphate 
• 50-99-7 D-glucose 

Downstream Products

• 3615-55-2 D-ribose 5-phosphate 
• 551-85-9 Ribulose-5-phosphate 
• 526-95-4 gluconic acid 

Relevant articles and documents

Complete Oxidation of Sugars to Electricity by Using Cell-Free Synthetic Enzymatic Pathways

The present invention is in the field of bioelectricity. The present invention provides energy generating systems, methods, and devices that are capable of converting chemical energy stored in sugars into useful electricity.

Pyrazine-derived disulfide-reducing agent for chemical biology

For fifty years, dithiothreitol (DTT) has been the preferred reagent for the reduction of disulfide bonds in proteins and other biomolecules. Herein we report on the synthesis and characterization of 2,3-bis(mercaptomethyl)pyrazine (BMMP), a readily accessible disulfide-reducing agent with reactivity under biological conditions that is markedly superior to DTT and other known reagents. This journal is the Partner Organisations 2014.

Para-hydrogenated glucose derivatives as potential 13c- hyperpolarized probes for magnetic resonance imaging

A set of molecules in which a glucose moiety is bound to a hydrogenable synthon has been synthesized and evaluated for hydrogenation reactions and for the corresponding para-hydrogen-induced polarization (PHIP) effects, in order to select suitable candidates for an in vivo magnetic resonance imaging (MRI) method for the assessment of glucose cellular uptake. It has been found that amidic derivatives do not yield any polarization enhancement, probably due to singlet-triplet state mixing along the reaction pathway. In contrast, ester derivatives are hydrogenated in high yield and afford enhanced 1H and 13C NMR spectra after para-hydrogenation. The obtained PHIP patterns are discussed and explained on the basis of the calculated spin level populations in the para-hydrogenated products. These molecules may find interesting applications in 13C MRI as hyperpolarized probes for assessing the activity of glucose transporters in cells.

Genome-wide screening reveals the genetic determinants of an antibiotic insecticide in Bacillus thuringiensis

Thuringiensin is a thermostable secondary metabolite in Bacillus thuringiensis and has insecticidal activity against a wide range of insects. Until now, the regulatory mechanisms and genetic determinants involved in thuringiensin production have remained unclear. Here, we successfully used heterologous expression-guided screening in an Escherichia coli-Bacillus thuringiensis shuttle bacterial artificial chromosome library, to clone the intact thuringiensin synthesis (thu) cluster. Then the thu cluster was located on a 110-kb endogenous plasmid bearing insecticide crystal protein gene cry1Ba in strain CT-43. Furthermore, the plasmid, named pBMB0558, was indirectly cloned and sequenced. The gene functions on pBMB0558 were annotated by BLAST based on the GenBank and KEGG databases. The genes on pBMB0558 could be classified into three functional modules: a thuringiensin synthesis cluster, a type IV secretion system-like module, and mobile genetic elements. By HPLC coupling mass spectrometer, atmospheric pressure ionization with ion trap, and TOF technologies, biosynthetic intermediates of thuringiensin were detected. The thuE gene is proved to be responsible for the phosphorylation of thuringiensin at the last step by vivo and vitro activity assays. The thuringiensin biosynthesis pathway was deduced and clarified. We propose that thuringiensin is an adenine nucleoside oligosaccharide rather than an adenine nucleotide analog, as is traditionally believed, based on the predicted functions of the key enzymes, glycosyltransferase (ThuF) and exopolysaccharide polymerization protein (Thu1).

Reactivity of some sugars and sugar phosphates towards gold(III) in sodium acetate-acetic acid buffer medium

The kinetics of the oxidation of some aldoses and aldose phosphates have been studied spectrophotometrically in sodium acetate-acetic acid buffer medium at different temperatures. The reactions are first order with respect to [Au(III)] and [substrate]. Both H+ and Cl- ions retard the reaction. The reactions appear to involve different gold(III) species, viz. AuCl4/-, AuCl3(OH2) and AuCl3(OH)-. The results are interpreted in terms of the probable intermediate formation of free radicals and Au(II). Aldoses react with gold(III) in the order: triose > tetrose > pentose > hexose. The sugar phosphates react with gold(III) at a faster rate than the parent sugars except glucose-1-phosphate, which reacts at slower rates than glucose. A tentative reaction mechanism leading to the formation of products has been suggested.

Reactivities of some sugar phosphates towards permanganate in perchloric acid medium and mechanism of the oxidation processes

The reactivities of some sugar phosphates towards permanganate have been examined in perchloric acid medium. The reactions are first order in [sugar phosphate] and [MnO4-]. The rate increases with increase in [H+]. The reactivities follow the order: erythrose 4-phosphate> ribose 5-phosphate> fructose 1,6-diphosphate> glucose 6-phosphate> glucose 1-phosphate. The mechanism of the reactions is discussed.

Enzyme-Catalyzed Organic Synthesis: NAD(P)H Cofactor Regeneration by Using Glucose 6-Phosphate and the Glucose-6-Phosphate Dehydrogenase from Leuconostoc mesenteroides

Glucose 6-phosphate dehydrogenase (from Leuconostoc mesenteroides) and glucose 6-phosphate comprise a useful system for regeneration of reduced nicotinamide cofactors for use in enzyme-catalyzed organic sysnthesis.This enzyme is approximately equally active in reduction of NAD and NADP.It is commercially available, inexpensive, stable, and easily immobilized.Glucose 6-phosphate can be prepared in quantity by hexokinase-catalysed phosphorylation of glucose by ATP (coupled with ATP regeneration) or by other methods.The operation in this regeneration system is illustrated by syntheses of enantiomerically enriched D-lactic acid (0.4 mol, enantiomeric excess 95percent) and (S)-benzyl-α-d1 alcohol (0.4 mol, enantiomeric excess 95percent) and by synthesis of treo-DS(+)-isocitric acid (0.17 mol).Factors influencing the stability of NAD(P)(H) in solution have been explored.