921207-63-8Relevant academic research and scientific papers
PYRIDINYL AND FUSED PYRIDINYL TRIAZOLONE DERIVATIVES
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Paragraph 0253-0254, (2014/09/29)
Disclosed are compounds of Formula 1, or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, and R4 are defined in the specification. This disclosure also relates to materials and methods for preparing compounds of Formula 1, to pharmaceutical compositions which contain them, and to their use for treating Type I hypersensitivity reactions, autoimmune diseases, inflammatory disorders, cancer, non-malignant proliferative disorders, and other conditions associated with BTK.
Total synthesis of (+)-varitriol and (+)-6′-epi-varitriol
Vamshikrishna,Srihari
experimental part, p. 1540 - 1546 (2012/02/17)
Total synthesis of (+)-varitriol and its C6′-epimer have been achieved starting from commercially available d-(-)-ribose and o-anisic acid. The key steps involved are Corey Chaykovsky reaction, triethylamine mediated epimerization, and an olefin cross-met
De novo formal synthesis of (-)-apicularen A via an iterative asymmetric hydration sequence
Li, Miaosheng,O'Doherty, George A.
, p. 6087 - 6090 (2007/10/03)
(Chemical Equation Presented) A de novo approach to the formal total synthesis of the macrolide natural product (-)-apicularen A has been achieved in 18 steps'from achiral starting materials. Both the absolute and relative stereochemistries of apicularen A were introduced by a Sharpless asymmetric dihydroxylation, a π-allyl-palladium catalyzed reduction, a stereoselective reduction, and a base-promoted transannulation to install the C-9 stereocenter.
