145645-18-7Relevant academic research and scientific papers
Stereoselective Formal Synthesis of (-)-Salicylihalamides A and B Via Prins Cyclisation
Yadav,Venkateswar Rao,Purushothama Rao,Sridhar Reddy,Prasad
, p. 457 - 460 (2011/09/14)
A stereoselective and convergent formal approach to Salicylihalamide A and B is achieved through our recently developed strategy for the construction of polyketide precursors via Prins cyclisation. The approach mainly relies upon reductive opening of 1-iodomethyl cyclic ethers, Mitsunobu inversion and ring closing metathesis along with Prins cyclisation.
De novo formal synthesis of (-)-apicularen A via an iterative asymmetric hydration sequence
Li, Miaosheng,O'Doherty, George A.
, p. 6087 - 6090 (2007/10/03)
(Chemical Equation Presented) A de novo approach to the formal total synthesis of the macrolide natural product (-)-apicularen A has been achieved in 18 steps'from achiral starting materials. Both the absolute and relative stereochemistries of apicularen A were introduced by a Sharpless asymmetric dihydroxylation, a π-allyl-palladium catalyzed reduction, a stereoselective reduction, and a base-promoted transannulation to install the C-9 stereocenter.
Synthesis of the core structure of apicularen a by transannular cyclization.
Kuehnert, Sven M,Maier, Martin E
, p. 643 - 646 (2007/10/03)
[reaction: see text] An approach to the macrocyclic core of apicularen A is described. Thus, cross-coupling of the aryl triflate 7 with the vinylstannane 19 provided the styrene 20. Deprotection led to the dihydroxy acid 22. Through a size-selective macro
Synthesis of a model system for the macrocyclic subunit of the oximidines
Scheufler,Maier
, p. 1221 - 1224 (2007/10/03)
Cross-coupling reaction of aryl triflate 1 and vinyl stannane 13 provided salicylic acid derivative 15. This compound was converted to the dihydroxy acid 16, which provided in a size-selective macrolactonization the two macrolides 17 and 18 in a ratio of 60:40. Compound 17 is a model of the macrocyclic core of the oximidines.
Regioselectivity in the Reductive Cleavage of Pyrogallol Derivatives: Reductive Electrophilic Substitution of Acetals of 2,3-Dimethoxyphenol
Azzena, Ugo,Melloni, Giovanni,Pisano, Luisa
, p. 261 - 266 (2007/10/02)
Acetals of 2,3-dimethoxyphenol were used as the starting materials for the transformation of 1,2,3-trioxygenated benzenes into various 1-oxygenated-2,3-dicarbon-substituted benzenes, via regioselective reductive electrophilic substitution of the 2-methoxy
Reductive Electrophilic Substitution of Pyrogallol Derivatives: Synthesis of 2,3-Disubstituted Phenols
Azzena, Ugo,Melloni, Giovanni,Pisano, Luisa
, p. 5635 - 5638 (2007/10/02)
1,2-Dimethoxy-3-methoxymethoxybenzene, 1, was used as the starting material for the transformation of a 1,2,3-trioxybenzene into various 1-oxy-2,3-dicarbobenzenes, via regioselective reductive electrophilic substitution of the 2-methoxy group followed by
