921207-67-2

Upstream product

• 565473-04-3 ((hept-6-yn-1-yloxy)methyl)benzene 
• 693-02-7 hex-1-yne 
• 1002-36-4 hep-2-yn-1-ol 
• 63478-76-2 1-hydroxy-6-heptyne 
• 921207-66-1 ethyl 8-benzyloxy-oct-2-ynoate 

Downstream Products

• 570397-58-9 (3S,5R,7R)-7-(benzyloxy)-3-[3-(benzyloxy)propyl]-5-hydroxy-14-methoxy-3,4,5,6,7,8-hexahydro-1H-2-benzoxacyclododecin-1-one 
• 921207-73-0 methyl 2-{(1E,4R)-4-benzyloxy-5-[(2S,4R,6S)-6-(3-benzyloxy-propyl)-2-phenyl-1,3-dioxan-4-yl]pent-1-enyl}-6-methoxy-benzoate 
• 921207-64-9 (4R)-4-benzyloxy-5-[(2S,4R,6S)-6-(3-benzyloxy-propyl)-2-phenyl-1,3-dioxan-4-yl]pent-1-ene 
• 921207-71-8 (4R)-5-[(2S,4S,6S)-6-(3-benzyloxy-propyl)-2-phenyl-1,3-dioxan-4-yl]pent-1-en-4-ol 
• 921207-70-7 5-{(2S,4S,6S)-6-[3-(benzyloxy)propyl]-2-phenyl-1,3-dioxan-4-yl}-1-penten-4-one 
• 921207-65-0 ethyl 2-{(2S,4S,6S)-6-[3-(benzyloxy)propyl]-2-phenyl-1,3-dioxan-4-yl}acetate 
• 921207-68-3 ethyl (E)-(5S)-8-(benzyloxy)-5-hydroxy-2-octenoate 

Relevant academic research and scientific papers

De novo formal synthesis of (-)-apicularen A via an iterative asymmetric hydration sequence

(Chemical Equation Presented) A de novo approach to the formal total synthesis of the macrolide natural product (-)-apicularen A has been achieved in 18 steps'from achiral starting materials. Both the absolute and relative stereochemistries of apicularen A were introduced by a Sharpless asymmetric dihydroxylation, a π-allyl-palladium catalyzed reduction, a stereoselective reduction, and a base-promoted transannulation to install the C-9 stereocenter.