921224-79-5Relevant academic research and scientific papers
Straightforward synthesis of (S)- and (R)-α-trifluoromethyl proline from chiral oxazolidines derived from ethyl trifluoropyruvate
Chaume, Gregory,Van Severen, Marie-Celine,Marinkovic, Sinisa,Brigaud, Thierry
, p. 6123 - 6126 (2007/10/03)
(Chemical Equation Presented) A concise synthesis of both enantiomers of α-Tfm-proline and (S)-α-Tfm-prolinol from ethyl trifluoropyruvate is reported. The key step is a diastereoselective allylation reaction of ethyl trifluoropyruvate and (R)-phenylglyci
