921224-77-3

Upstream product

• 921224-73-9 (1R)-N-[(E)-1-ethoxycarbonyl-2,2,2-trifluoroethylidene]-(2-tert-butyldimethylsilyloxy-1-phenylethyl)amine 
• 762-72-1 allyl-trimethyl-silane 
• 13081-18-0 ethyl-3,3,3-trifluoropyruvate 
• 56613-80-0 D-2-phenylglycinol 
• 1094092-25-7 (4R)-2-ethoxycarbonyl-2-trifluoromethyl-4-phenyl-1,3-oxazolidine 
• 67341-01-9 (R)-N-(tert-butoxycarbonyl)phenylglycinol 
• 120417-13-2 (1R)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-phenylethanamine 

Downstream Products

• 921224-82-0 (S)-α-trifluoromethyl-proline 
• 921224-81-9 (4R,8aS)-8a-trifluoromethyl-4-phenyl-hexahydro-pyrrolo[2,1-c][1,4]oxazin-1-one 
• 921224-82-0 (R)-α-trifluoromethyl-proline 
• 921224-79-5 (3S,5R)-3-propyl-3-trifluoromethyl-5-phenylmorpholin-2-one 

Relevant academic research and scientific papers

Synthesis of an MIF-1 analogue containing enantiopure (S)-α- trifluoromethyl-proline and biological evaluation on nociception

The synthesis and the effect of a novel MIF-1 analogue on nociception during acute pain in rat model are reported. The synthesis of this enantiopure trifluoromethyl group containing tripeptide was performed through a peptide coupling reaction between the HCl. Leu-Gly-NH2 and the (S)-α-Tfm-proline. The analgesic effect of the CF3-(MIF-1) 2 has been evaluated in vivo on rat model by paw pressure (PP) and hot plate (HP) tests and compared to the native peptide MIF-1. Highest analgesic effect was observed with CF3-(MIF-1) 2 only in PP test. In order to study the mechanisms of nociception induced by the studied peptides, the involvement of the opioid and the nitric oxideergic systems was investigated. The results are in favor of a participation of both system since pretreatment, 20 min before injection of the CF3-(MIF-1) 2, with the non-competitive antagonist of opiate receptors naloxone, the nitric oxide synthase (NOS) inhibitor l-N G-nitroarginine ester (l-NAME) or the nitric oxide (NO) donor l-arginine (l-Arg) significantly decreased the pain perception in PP and HP tests.

Convenient synthesis of N-Terminal Tfm-Dipeptides from unprotected enantiopure α-Tfm-Proline and α-Tfm-alanine

A convenient procedure for the synthesis of highly lipophilic dipeptide building blocks from enantiopure α-trifluoromethyl α-amino acids is reported. Coupling reactions at the C termini of the trifluoromethyl a-amino acids were successfully performed with

Iodocyclization of chiral cf3-allylmorpholinones: A versatile strategy for the synthesis of enantiopure α-Tfm-prolines and α-Tfm-dihydroxyprolines

An efficient iodocyclization reaction of a chiral Tfm-allylmorpholinone provides a straightforward route to α-Tfm-prolines and α-Tfmdihydroxyprolines. The methodologies developed are particularly well adapted for gram-scale synthesis of enantiopure compou

Concise access to enantiopure (S)- and (R)-α-trifluoromethyl pyroglutamic acids from ethyl trifluoropyruvate-based chiral CF3-oxazolidines (Fox)

A straightforward synthesis of enantiopure (S)- and (R)-α-Tfm-pyroglutamic acid is reported. The strategy is based on the use of a chiral CF3-hydroxymorpholinone intermediate conveniently obtained from ethyl trifluoropyruvate-based chiral CFsu

Straightforward synthesis of (S)- and (R)-α-trifluoromethyl proline from chiral oxazolidines derived from ethyl trifluoropyruvate

(Chemical Equation Presented) A concise synthesis of both enantiomers of α-Tfm-proline and (S)-α-Tfm-prolinol from ethyl trifluoropyruvate is reported. The key step is a diastereoselective allylation reaction of ethyl trifluoropyruvate and (R)-phenylglyci