92126-19-7

Upstream product

• 762-42-5 dimethyl acetylenedicarboxylate 
• 6947-29-1 N’-(4-chlorophenyl)acetohydrazide 
• 106-47-8 4-chloro-aniline 
• 141-97-9 ethyl acetoacetate 
• 27143-09-5 ethyl 2-chloro-2-(4-chlorophenylhydrazono)acetate 

Downstream Products

• 92126-24-4 Methyl-carbamic acid 1-(4-chloro-phenyl)-5-methyl-3-methylcarbamoyloxymethyl-1H-pyrazol-4-ylmethyl ester 
• 92126-21-1 [1-(4-Chloro-phenyl)-3-hydroxymethyl-5-methyl-1H-pyrazol-4-yl]-methanol 

Relevant academic research and scientific papers

Rhodium-catalyzed addition-cyclization of hydrazines with alkynes: Pyrazole synthesis via unexpected C-N bond cleavage

Rhodium-catalyzed addition-cyclization of hydrazines with alkynes has been achieved to afford highly substituted pyrazoles under mild conditions. The cascade reaction involves two transformations: addition of the C-N bond of hydrazines to alkynes via unex

Synthesis and evaluation of furan, thiophene, and azole bis[(carbamoyloxy)methyl] derivatives as potential antineoplastic agents

A series of bis(hydroxymethyl)-substituted heterocycles were synthesized and converted to the corresponding bis(methylcarbamate) derivatives. The heterocyclic systems studied were based on 2-phenyl-3-methylfuran, 1-phenylpyrazole, 1-phenyl-5-methylpyrazole, 1-phenyl-5-methylthiopene, 1-phenyl-1,2,3-triazole, 3-phenylisoxazole, 3-phenylisothiazole, 2-phenylthiazole, and 2-phenyloxazole. None of the bis(carbamates) prepared was active against murine P388 lymphocytic leukemia. Pyrrole bis(carbamate), which exhibited antileukemic activity, also showed reactivity toward 4-(p-nitrobenzyl)pyridine while the inactive bis(carbamates) were unreactive in the 4-(p-nitrobenzyl)pyridine assay.