6947-29-1

Upstream product

• 17333-85-6 4-chlorophenyldiazonium salt 
• 579-07-7 1-Phenylpropane-1,2-dione 
• 108-24-7 acetic anhydride 
• 1073-69-4 N-4-chlorophenylhydrazine 
• 106-47-8 4-chloro-aniline 
• 64-19-7 acetic acid 
• 100-63-0 phenylhydrazine 
• 70638-34-5 2-(4-chloro-phenylazo)-2,5-dimethyl-furan-3-one 
• 1073-70-7 4-chlorophenylhydrazine hydrochloride 

Downstream Products

• 804-88-6 4-(4-chloro-phenyl)-2-methyl-6,6-diphenyl-4H-[1,3,4]oxadiazin-5-one 
• 1073-69-4 N-4-chlorophenylhydrazine 
• 681860-24-2 N,N'-dimethyl-N'-(4-chlorophenyl)acetohydrazide 
• 1312713-62-4 1-(8-(4-chlorophenyl)-3-(2-fluorophenyl)-1-oxa-2,7,8-triazaspiro[4.4]non-2-en-7-yl)ethanone 
• 1450812-51-7 N'-(4-chlorophenyl)-N'-methylacetohydrazide 
• 92126-19-7 dimethyl 1-(4-chlorophenyl)-5-methyl-1H-pyrazole-3,4-dicarboxylate 
• 39195-66-9 2-(4-chlorophenyl)benzofuran 
• 1657-50-7 (E)-1-(4-chlorophenyl)-2-phenylethene 
• 52598-02-4 2,3-diphenyl-5-chloro-1H-indole 
• 906781-10-0 2-(4-chlorophenyl)-1H-benzo[g]indole 

Relevant academic research and scientific papers

Palladium/copper-catalyzed arylation of alkenes with N′-acyl arylhydrazines

A novel ligand-free palladium/copper-catalyzed Heck-type coupling reaction of alkenes and N′-acyl arylhydrazines has been developed by using air as the terminal oxidant. This protocol features wide functional group tolerance and produces highly chemoselective and regioselective products with good to excellent yields.

Synthesis of 2,3-dihydro-1H-indazoles by Rh(iii)-catalyzed C-H cleavage of arylhydrazines

A rhodium-catalyzed efficient method for the synthesis of 2,3-dihydro-1H-indazoles is described. The reaction of arylhydrazines with olefins results in the corresponding 2,3-dihydro 1H-indazoles with exclusive regioselectivity via C-H bond activation. The utility of the methodology is illustrated by a rapid synthesis of 1H-indazoles under mild reaction conditions in half an hour. This journal is the Partner Organisations 2014.

Rh(III)-catalyzed oxidative coupling of 1,2-disubstituted arylhydrazines and olefins: A new strategy for 2,3-dihydro-1H-indazoles

A rhodium(III)-catalyzed oxidative olefination of 1,2-disubstituted arylhydrazines with alkenes via sp2 C-H bond activation followed by an intramolecular aza-Michael reaction is described. This strategy allows the direct and efficient construct

Indole synthesis by rhodium(III)-catalyzed hydrazine-directed C-H activation: Redox-neutral and traceless by N-N bond cleavage

Fishing for complements! There is an alternative to the useful Fischer indole synthesis. The new method utilizes the same retrosynthetic disconnection but is based on a RhIII-catalyzed directed C-H activation step and a successive coupling with alkynes. Copyright

Formation of enehydrazine intermediates through coupling of phenylhydrazines with vinyl halides: Entry into the Fischer indole synthesis

Cut to the chase: Direct formation of an enehydrazine, an intermediate in the classic Fischer indole synthesis, solves the regioselectivity problem associated with indolization. This approach not only achieves selective synthesis of indoles through proper selection of the vinyl halide, but also leads to quick construction of desoxyeseroline and esermethole, as well as the key structural motif in the Akuammiline alkaloid vincorine. Copyright

Synthesis of spiro-fused pyrazolidoylisoxazolines

Routes to structurally unique spiro-fused pyrazolidoylisoxazolines are reported. These methods start with monosubstituted hydrazines or hydrazides and utilize the nitrile oxide 1,3-dipolar cycloaddition reaction to generate the targeted spiro-fused bis-he

Pyridoindolone derivatives substituted in the 3-position by a phenyl, their preparation and their application in therapeutics

The present invention relates to pyridoindolone derivatives substituted in the 3-position by a phenyl of general formula (I): to processes for preparing the same and to their use in therapeutics.

Addition of Semidione Radicals to Arenediazonium Ions: Synthesis of 1,1-Diacyl-2-arylhydrazines

The α-dicarbonyl compounds 1 are selectively reduced to semidione radicals 2 by aqueous Ti3+, via inner-sphere electron transfer (ET).When an equimolar amount of an arenediazonium salt (3) is present, 2 adds to the nitrogen-nitrogen triple bond of 3 to afford the intermediate azo radical cation C, which, depending on the nature of the para substituent of the N-phenyl ring, undergoes rearrangement to a 1,1-diacyl-2-arylhydrazine (4) or preferentially reduction to a hydrazone (5).A mechanism that accounts for both the rearrangement and the substituent effects that are observed is proposed.

Acylation Reactions of Phenylhydrazines. Preparation and Properties of New Diacylphenylhydrazines

Anhydride acylation reactions of a variety of substituted arylhydrazines under mild conditions led to controlled formation of the acid phenylhydrazides I (Table I).The procedures were tallored to the particular state of the starting arylhydrazine.Second-s

REACTION OF 2-ARYLAZO-2,5-DIMETHYL-3(2H)-FURANONES WITH AMMONIA. PREPARATION OF β-ACETYL-β-(3-AMINO-2-BUTENOYL)ARYLHYDRAZINES.

Ring opening of 2-arylazo-2,5-dimethyl-3(2H)-furanones (1a-d) with ammonia leads to previously unknown β-acetyl-β-(3-amino-2-butenoyl)arylhydrazines (3a-d).The reaction mechanism is discussed.