92137-90-1

Usage

Uses

Used in Pharmaceutical Research and Development:
2,6-Piperidinedione, 3-(4-aminophenyl)is used as a GABA reuptake inhibitor for its potential therapeutic effects on conditions such as anxiety, depression, and other neurological disorders. Its ability to inhibit GABA reuptake may help in managing the symptoms of these conditions by modulating the levels of GABA in the brain.
Used in Antimicrobial Applications:
2,6-Piperidinedione, 3-(4-aminophenyl)is used as an antimicrobial agent for its potential to combat bacterial infections. Its antimicrobial properties make it a compound of interest in the development of new antibiotics to address the growing issue of antibiotic resistance.
Used in Antifungal Applications:
2,6-Piperidinedione, 3-(4-aminophenyl)is used as an antifungal agent for its potential to treat fungal infections. Its antifungal properties make it a promising candidate for the development of new antifungal drugs to combat the increasing prevalence of drug-resistant fungal pathogens.

Upstream product

• 14149-34-9 3-phenyl-2,6-piperidine-dione 
• 106-40-1 4-bromo-aniline 
• 214360-73-3 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)aniline 
• 140-29-4 phenylacetonitrile 
• 91137-66-5 2-phenylpentanedinitrile 
• 92137-91-2 3-(4-nitrophenyl)piperidine-2,6-dione 

Relevant academic research and scientific papers

DEGRADATION OF (EGFR) BY CONJUGATION OF EGFR INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE

Disclosed herein are novel bifunctional compounds formed by conjugating EGFR inhibitor moieties with E3 ligase ligand moieties, which function to recruit targeted proteins to E3 ubiquitin ligase for degradation, and methods of preparation and uses thereof.

Aromatase Inhibitors. Synthesis and Evaluation of Mammary Tumor Inhibiting Activity of 3-Alkylated 3-(4-Aminophenyl)piperidine-2,6-diones

The synthesis and biological evaluation of 3-alkyl-substituted 3-(4-aminophenyl)piperidine-2,6-diones as inhibitors of estrogen biosynthesis are described .In vitro compounds 4-14 showed a stronger inhibition of human placental aromatase compared to aminoglutethimide (AG, compound 3), which recently has become used for the treatment of hormone-dependent breast cancer.The most active derivative, compound 10, showed a 93-fold stronger inhibition than AG.With the exception of 5, 7, and 8, all other compounds exhibited similar or decreased inhibition of bovine adrenal desmolase compared to AG.Compounds 4 and 6-12 showed a stronger inhibition of the plasma estradiol concentration of pregnant mare serum gonadotropin (PMSG) primed Sprague-Dawley (SD) rats compared to the parent compound.Compounds 4, 6-8, 10, and 12 inhibited the testosterone-stimulated tumor growth of ovariectomized 9,10-dimethyl-1,2-benzanthracene (DMBA) tumor-bearing SD rats more strongly than AG.Being stronger and more selective inhibitors of the estrogen biosynthesis than AG, some of the newly developed derivatives of AG might be better candidates for the treatment of the hormone-dependent human breast cancer.