92138-25-5Relevant articles and documents
Synthesis of protected norcysteines for SPPS compatible with Fmoc strategy
Samant, Manoj P.,Rivier, Jean E.
, p. 5107 - 5110 (2008/02/09)
We report the synthesis of racemic Alloc-Ncy(Tmob)-OH, the resolution of its methyl ester and demonstrate its application to form a norcystine bridge in octreotide-amide using the Fmoc strategy on solid phase. N-Alloc and S-Tmob protections of norcysteine (Ncy) were found to be a preferred choice for Fmoc strategy over three other protected norcysteines synthesized, that is, Fmoc-Ncy(tBu)-OH, Alloc-Ncy(tBu)-OH, and Alloc-Ncy(Trt)-OH.