946524-10-3

Basic information

• Product Name: Alloc-D,L-Ncy(Tmob)-OH
• Synonyms: Alloc-D,L-Ncy(Tmob)-OH
• CAS NO: 946524-10-3
• Molecular Weight: 371.411
• Mol File: 946524-10-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Alloc-D,L-Ncy(Tmob)-OH(CAS DataBase Reference)
• NIST Chemistry Reference: Alloc-D,L-Ncy(Tmob)-OH(946524-10-3)
• EPA Substance Registry System: Alloc-D,L-Ncy(Tmob)-OH(946524-10-3)

Safety Data

• Hazardous Substances Data: 946524-10-3(Hazardous Substances Data)

Upstream product

• 92138-25-5 (RS)-N-<(allyloxy)carbonyl>-α-hydroxyglycine 
• 212555-23-2 (2,4,6-trimethoxyphenyl)methanethiol 

Downstream Products

• 946524-14-7 Alloc-D,L-Ncy(Tmob)-OCH₃ 
• 946524-03-4 Alloc-L-Ncy(Tmob)-OH 

Relevant articles and documents

Synthesis of protected norcysteines for SPPS compatible with Fmoc strategy

We report the synthesis of racemic Alloc-Ncy(Tmob)-OH, the resolution of its methyl ester and demonstrate its application to form a norcystine bridge in octreotide-amide using the Fmoc strategy on solid phase. N-Alloc and S-Tmob protections of norcysteine (Ncy) were found to be a preferred choice for Fmoc strategy over three other protected norcysteines synthesized, that is, Fmoc-Ncy(tBu)-OH, Alloc-Ncy(tBu)-OH, and Alloc-Ncy(Trt)-OH.