92143-66-3 Usage
Uses
Used in Research Applications:
(9-Acridinyl)-putrescine is used as a research tool for studying DNA intercalation and probing the binding sites of DNA and polyamine ligands. Its unique structure allows for a better understanding of the interactions between DNA and other molecules, which can be crucial in the development of new therapeutic strategies.
Used in Anticancer Applications:
In the field of oncology, (9-Acridinyl)-putrescine is used as a potential anticancer agent, particularly against human solid tumors. Its ability to bind selectively to DNA makes it a promising candidate for further research and development in cancer therapy.
Used in Drug Delivery Systems:
(9-Acridinyl)-putrescine has also been studied for its potential as a targeting agent in drug delivery systems. Its selective binding to DNA could be utilized to improve the delivery of therapeutic agents to cancer cells, enhancing the efficacy of treatments and reducing side effects.
Used in DNA-Protein and DNA-Drug Interaction Studies:
Furthermore, (9-Acridinyl)-putrescine is used as a probe for studying DNA-protein and DNA-drug interactions. This application can provide valuable insights into the mechanisms of action of various drugs and help in the design of more effective therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 92143-66-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,2,1,4 and 3 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 92143-66:
(7*9)+(6*2)+(5*1)+(4*4)+(3*3)+(2*6)+(1*6)=123
123 % 10 = 3
So 92143-66-3 is a valid CAS Registry Number.
InChI:InChI=1/C17H19N3/c18-11-5-6-12-19-17-13-7-1-3-9-15(13)20-16-10-4-2-8-14(16)17/h1-4,7-10H,5-6,11-12,18H2,(H,19,20)
92143-66-3Relevant academic research and scientific papers
In vitro efficiency of 9-(N-cinnamoylbutyl)aminoacridines against blood- and liver-stage malaria parasites
Perez, Bianca,Teixeira, Catia,Gomes, Ana S.,Albuquerque, Ines S.,Gut, Jiri,Rosenthal, Philip J.,Prudencio, Miguel,Gomes, Paula
supporting information, p. 610 - 613 (2013/03/13)
Novel 9-aminoacridine derivatives were synthesized by linking the heteroaromatic core to different cinnamic acids through an aminobutyl chain. The test compounds demonstrated mid-nanomolar in vitro activity against erythrocytic stages of the chloroquine-resistant W2 strain of the human malaria parasite Plasmodium falciparum. Two of the most active derivatives also showed in vitro activity against liver-stage Plasmodium berghei, with activity greater than that of the reference liver-stage antimalarial primaquine. The compounds were not toxic to human hepatoma cells at concentrations up to 5 μM. Hence, 9-(N-cinnamoylbutyl)aminoacridines are a new class of leads for prevention and treatment of malaria.
