92152-36-8

Basic information

• Product Name: 1-methyl-2-o-bromophenylbenzimidazole
• Synonyms: 1-methyl-2-o-bromophenylbenzimidazole;2-(2-Bromophenyl)-1-methyl-1H-benzimidazole;2-(2-Bromophenyl)-1-methyl-1H-benzo[d]imidazole;2-(2-bromophenyl)-1-methylbenzimidazole
• CAS NO: 92152-36-8
• Molecular Formula: C₁₄H₁₁BrN₂
• Molecular Weight: 287.15454
• Mol File: 92152-36-8.mol
• Article Data: 8

Chemical Properties

• Melting Point: 114-119°C
• Boiling Point: 430.2±47.0 °C(Predicted)
• Appearance: /
• Density: 1.43±0.1 g/cm3(Predicted)
• PKA: 4.61±0.10(Predicted)
• CAS DataBase Reference: 1-methyl-2-o-bromophenylbenzimidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-methyl-2-o-bromophenylbenzimidazole(92152-36-8)
• EPA Substance Registry System: 1-methyl-2-o-bromophenylbenzimidazole(92152-36-8)

Safety Data

• Hazard Codes: T,Xi
• Statements: 25-37/38-41
• Safety Statements: 26-39-45
• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: 3
• Hazardous Substances Data: 92152-36-8(Hazardous Substances Data)

Usage

Structure

Benzimidazole derivative with a methyl group and a bromine atom attached to the phenyl ring

Usage

Potential drug candidate for the treatment of various medical conditions

Studied for

Potential anti-cancer, anti-inflammatory, and anti-viral properties

Investigated for

Use as a fluorescent probe in biological imaging and as a photosensitizer in photodynamic therapy

Ongoing research

To explore the full range of potential applications and properties of this compound

Upstream product

• 13275-42-8 2-(2-bromophenyl)-benzimidazole 
• 74-88-4 methyl iodide 
• 88-65-3 2-bromobenzoic-acid 
• 348-54-9 2-Fluoroaniline 
• 61436-88-2 2-bromo-N-methylbenzamide 
• 1519051-15-0 2-bromo-N'-(2-fluorophenyl)-N-methylbenzimidamide 
• 95-54-5 1,2-diamino-benzene 
• 77-78-1 dimethyl sulfate 
• 4760-34-3 N-methyl-1,2-phenylenediamine 

Downstream Products

• 1357398-61-8 1-methyl-2-(2-(diisopropylphosphino)phenyl)-1H-benzoimidazole 
• 1357398-59-4 1-methyl-2-(2-(diphenylphosphino)phenyl)-1H-benzoimidazole 
• 1357398-60-7 1-methyl-2-(2-(dicyclohexylphosphino)phenyl)-1H-benzoimidazole 
• 1444017-97-3 2-(2-bromophenyl)-1-isopropyl-1H-benzoimidazole 
• 93-04-9 2-Methoxynaphthalene 
• 946147-49-5 benzo[4,5]imidazo[1,2-a]benzo[4,5]imidazo[1,2-c]quinazoline 
• 92189-36-1 N-methyl-2-(2-boronophenyl)benzimidazole 

Relevant articles and documents

Electrochemical Synthesis of Benzimidazoles via Dehydrogenative Cyclization of Amidines

The development of efficient and sustainable methodologies for the synthesis of N-heterocycles is a constant focus of organic synthesis. Herein an electrochemical method is reported for the synthesis of benzimidazoles through dehydrogenative cyclization of easily available N-aryl amidines. The reactions were conducted under simple constant current conditions in an undivided cell without need for catalysts, chemical oxidants, or additives, and produced H2 as the only theoretical byproduct.

Decarboxylative cross-coupling of mesylates catalyzed by copper/palladium systems with customized imidazolyl phosphine ligands

The activation of the inert C-O bonds in mesylates through the use of a new class of imidazolyl phosphines allows the decarboxylative coupling of aryl mesylates as well as polysubstituted alkenyl mesylates. Variation of the ligands leads to two complementary methods providing the corresponding biaryls and polysubstituted olefins in good yields. Copyright

Buchwald-Hartwig amination of aryl chlorides catalyzed by easily accessible benzimidazolyl phosphine-Pd complexes

This study describes the efficacy of benzimidazolyl phosphine ligands, which are easily synthesized from inexpensive and commercially available o-phenylenediamine, 2-bormobenzoic acid, and chlorophosphines, in the Buchwald-Hartwig amination of aryl chlorides. Primary and secondary aromatic/aliphatic amines are effective substrates in this catalytic system. Functional groups such as keto and esters are also compatible. The catalyst loading can be reduced to 0.1 mol% Pd. Georg Thieme Verlag Stuttgart · New York.