921605-76-7

Basic information

• Product Name: tert-butyl 4-(2-(trifluoromethyl)phenoxy)piperidine-1-carboxylate
• Synonyms: tert-butyl 4-(2-(trifluoromethyl)phenoxy)piperidine-1-carboxylate;1-Boc-4-(2-(trifluoroMethyl)phenoxy)piperidine;4-[2-(Trifluoromethyl)phenoxy]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester;1-Piperidinecarboxylic acid, 4-[2-(trifluoroMethyl)phenoxy]-, 1,1-diMethylethyl ester
• CAS NO: 921605-76-7
• Molecular Formula: C₁₇H₂₂F₃NO₃
• Molecular Weight: 345.3566896
• Mol File: 921605-76-7.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 394.295 °C at 760 mmHg
• Flash Point: 192.263 °C
• Appearance: /
• Density: 1.200
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.487
• Storage Temp.: 2-8°C
• PKA: -2.48±0.40(Predicted)
• CAS DataBase Reference: tert-butyl 4-(2-(trifluoromethyl)phenoxy)piperidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 4-(2-(trifluoromethyl)phenoxy)piperidine-1-carboxylate(921605-76-7)
• EPA Substance Registry System: tert-butyl 4-(2-(trifluoromethyl)phenoxy)piperidine-1-carboxylate(921605-76-7)

Safety Data

• Hazardous Substances Data: 921605-76-7(Hazardous Substances Data)

Usage

General Description

Tert-butyl 4-(2-(Trifluoromethyl)phenoxy)piperidine-1-carboxylate is a chemical compound with the molecular formula C17H23F3NO3. It is a piperidine derivative with a tert-butyl ester group and a trifluoromethylphenyl substituent. tert-butyl 4-(2-(Trifluoromethyl)phenoxy)piperidine-1-carboxylate is commonly used in the pharmaceutical and agrochemical industries as a building block for the synthesis of various products. It may also have potential applications in research and development of new drugs or agrochemicals due to its unique structural features. Additionally, its tert-butyl ester group can provide stability and alter the physicochemical properties of the molecule, making it valuable for diverse applications.

InChI:InChI=1/C17H22F3NO3/c1-16(2,3)24-15(22)21-10-8-12(9-11-21)23-14-7-5-4-6-13(14)17(18,19)20/h4-7,12H,8-11H2,1-3H3

Upstream product

• 109384-19-2 t-butyl 4-hydroxy piperidine-1-carboxylate 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 444-30-4 2-(trifluoromethyl)phenol 
• 118811-07-7 tert-butyl 4-(tosyloxy)piperidin-1-carboxylate 
• 603-35-0 triphenylphosphine 

Downstream Products

• 1085784-05-9 methyl 6-({[(4-amino-2-{4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl}-1,3-thiazol-5-yl)carbonyl]amino}carbonyl)nicotinate 
• 1085784-14-0 5-({[(5-methyl-1,3,4-oxadiazol-2-yl)methyl]amino}methyl)-2-{4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl}[1,3]thiazolo[4,5-d]pyrimidin-7(6H)-one 
• 1085784-06-0 methyl 6-(7-oxo-2-{4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl}-6,7-dihydro[1,3]thiazolo[4,5-d]pyrimidin-5-yl)nicotinate 
• 1085783-87-4 5-[(pyridin-2-ylthio)methyl]-2-{4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl}[1,3]thiazolo[4,5-d]pyrimidin-7(6H)-one 
• 1085784-48-0 ethyl ({2-[4-(2-trifluoromethylphenoxy)piperidin-1-yl]-5-methyl[1,3]thiazolo[4,5-d]pyrimidin-7-yl}oxy)acetate 
• 1085783-85-2 3-(7-oxo-2-{4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl}-6,7-dihydro[1,3]thiazolo[4,5-d]pyrimidin-5-yl)propanoic acid 
• 1085783-84-1 methyl 3-(7-oxo-2-{4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl}-6,7-dihydro[1,3]thiazolo[4,5-d]pyrimidin-5-yl)propanoate 
• 1085784-46-8 ({2-[4-(2-trifluoromethylphenoxy)piperidin-1-yl]-5-methyl[1,3]thiazolo[4,5-d]pyrimidin-7-yl}oxy)acetic acid 
• 1085783-83-0 methyl 7-oxo-2-{4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl}-6,7-dihydro[1,3]-thiazolo[4,5-d]pyrimidine-5-carboxylate 
• 1085784-47-9 2-[4-(2-trifluoromethylphenoxy)piperidin-1-yl]-7-chloro-5-methyl[1,3]thiazolo[4,5-d]pyrimidine 
• 936716-41-5 methyl N-cyano-[2-(trifluoromethyl)phenoxy]piperidine-1-carbimidothioate 
• 936716-42-6 4-amino-2-{4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl}-1,3-thiazole-5-carboxamide 
• 936716-49-3 5-(chloromethyl)-2-{4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl}[1,3]thiazolo[4,5-d]pyrimidin-7(6H)-one 
• 936716-48-2 5-methyl-2-{4-[2-trifluoromethyl-phenoxy]piperidin-1-yl}-6H-[1,3]thiazolo[4,5-d]pyrimidin-7-one 

Relevant articles and documents

BISPECIFIC ANTAGONISTS OF RETINOL-BINDING PROTEIN 4 THAT STABILIZE TRANSTHYRETIN TETRAMERS, THEIR PREPARATION, AND USE IN THE TREATMENT OF COMMON AGE-RELATED COMORBIDITIES

The present invention provides a compound having the structure: Formula (I) wherein X is CR6 or N; R1, R2, R3, R4, and R6 are each independently -H, -F, -Cl, -Br, -I, -NO2, -CN, -CF3, -CF2H, -OCF3, -(alkyl), -(haloalkyl), -(alkenyl), -(alkynyl), -(aryl), -(heteroaryl), -(cycloalkyl), -(cycloalkylalkyl), -(heteroalkyl), heterocycle, heterocycloalkyl, -(alkylheteroalkyl), -(alkylaryl), -OH, -OAc, -0-(alkyl), -0-(alkenyl), -0-(alkynyl), -0-(aryl), -O- (heteroaryl), -SH, -S-(alkyl), -S-(alkenyl), -S-(alkynyl), -S- (aryl), -S-(heteroaryl), -NH2, -NH-(alkyl), -NH-(alkenyl), -NH- (alkynyl), -NH-(aryl), -NH-(heteroaryl), -C(O)R7, -S(O)R7, SO2R7, -NHSO2R7, -OC(O)R7, -SC(O)R7, -NHC(O)R8 or -NHC(S)R8, wherein R7 is, H, -(alkyl), -OH, -O(alkyl), -NH2, -NH(alkyl) or -N(alkyl)2, and wherein R6 is, -(alkyl), -O-(alkyl), -NH2, -NH(alkyl) or N(alkyl)2; Y is O, S, Ν, ΝΗ, or a bond; Z is O, S, N, NH, (CH2)O, or a bond; R5 is H, OH, halogen, alkyl, or R5 is (CH2)P and is bound to Y when Y is N to form a ring together with Z; o and p are independently 0, 1, 2, or 3; m and n are independently 0, 1, 2, 3, or 4; A, C, and D are each independently N or CR9; R9 is H, halogen, -OH, alkyl, cycloalkyl, cycloalkylalkyl, -O-(alkyl), -S-(alkyl), -NH2, -NH(alkyl), NH(alkyl)2, -CO2H, -CO(O-alkyl); B and E are N, CR9, or CFG wherein at least one of B or E is CFG; F is absent or present, and when present is Formula (II), Formula (III) G is H, substituted or unsubstituted monocycle, bicycle, heteromonocycle, heterobicycle, aryl, heteroaryl, alkyl, cycloalkyl, cycloalkylalkyl, CO2H, COOR10, OH, OR10, NH2, NHR10, NR10R11, SO2 (alkyl), SO2 (cycloalkyl), SO2(cycloalkylalkyl), CH2NHR10, CH2NR10R11, or CH2COOR10, wherein each R10 R11 are each independently H, alkyl, cycloalkyl, -C(O)-alkyl, -C(O)-cycloalkyl,-C(O)OH, -C(O)-O- alkyl, -C(O)-O-cycloalkyl, -C(O)NH2, -C(O)NH(alkyl), - C(O)NH(cycloalkyl), -C(O)N(alkyl)2, -CH2NH(alkyl), -CH2COOH, - SO2CH3, -OH, -O(alkyl), -NH2, -NH(alkyl), -N(alkyl)2, or a pharmaceutically acceptable salt thereof.

COMPOUNDS AND USES THEREOF

The present invention features compounds useful in the treatment of neurological disorders and primary brain cancer. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders and primary brain cancer.

NITROGEN HETEROCYCLE DERIVATIVES, PREPARATION THEREOF AND APPLICATION THEREOF IN HUMAN THERAPEUTICS

The present invention relates to compounds having general formula I characterised in that wherein in particular: R1 represents one or a plurality of groups such as: trifluoromethyl, halogen such as F, Cl, Br, methyl, nitro. R represents nitroge