92164-06-2

Upstream product

• 67-56-1 methanol 
• 91804-44-3 2-carboxy-2'-nitrodiphenyl ether 
• 1493-27-2 ortho-nitrofluorobenzene 
• 119-36-8 methyl salicylate 
• 88-73-3 2-Chloronitrobenzene 
• 54106-40-0 1-methyl-2-(2-nitrophenoxy)benzene 

Downstream Products

• 3158-85-8 10H-dibenzo[b,f][1,4]oxazepin-11-one 
• 59547-61-4 2-(2-nitro-phenoxy)-benzoic acid hydrazide 
• 171103-28-9 2-amino-2'-methyl diphenyl ether carboxylate 
• 62469-61-8 11-chloro-dibenz<1,4>oxazepine 
• 21636-40-8 11-(1-Piperazinyl)dibenz<1.4>oxazepin 

Relevant academic research and scientific papers

Synthesis and evaluation of antipsychotic activity of 11-(4-aryl-1- piperazinyl)-dibenz [b, f][1,4] oxazepines and their 8-chloro analogues

Atypical drugs reduce positive and negative symptoms of schizophrenia, without inducing EPS, but they exert other undesirable side effects. We have gone for synthesis of novel derivatives of Loxapine which are devoid of catalepsy and have decreased metabolic demethylation which is the prominent factor for bioavailability of the drug. While doing so we have also been successful in retaining the antipsychotic activity of the drug. Condensation of 8,11-dichlorodibenzoxazepine and 11-chlorodibenzoxazepine with 1-aryl piperazines was carried to give 8-chloro-11-(4-aryl-1-piperazinyl)-dibenz[b,f] [1,4]oxazepines and 11-(4-aryl-1-piperazinyl)-dibenz[b,f][1,4]oxazepines respectively. These derivatives were found as active as Clozapine.

Dibenzo-fused seven-membered nitrogen heterocycles by a tandem reduction-lactamization reaction

Efficient syntheses of dibenz[b,f][1,4]oxazepin-11(10H)-one, 5,10-dihydro-11H-dibenzo[b,e][1,4]-diazepin-11-one and 5,11-dihydro-6H-dibenz[b, e]azepin-6-one are described using a tandem reduction-lactamization sequence. Precursors for these ring systems are available in 1-3 steps using nucleophilic aromatic substitution and Ullmann coupling methodology. Direct reduction-lactamization of these compounds using iron powder in acetic acid at 115° affords the target heterocycles in ≥90% yield.

Loxapine analogs and methods of use thereof

The invention relates to novel compounds and methods of using them for modulating sleep.

Anti-inflammatory compounds

This invention relates to the novel compounds and pharmaceutical compositions of Formula (I). This invention also relates to a method of treating or reducing inflammation in a mammal in need thereof, which comprises administering to said mammal an eff