921928-01-0

Basic information

• Product Name: 2-Piperidinecarboxylic acid, 1-methyl-, 2,3,4,5,6-pentafluorophenyl ester, (2R)-
• CAS NO: 921928-01-0
• Molecular Formula: C13H12F5NO2
• Molecular Weight: 309.236
• Mol File: 921928-01-0.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: 2-Piperidinecarboxylic acid, 1-methyl-, 2,3,4,5,6-pentafluorophenyl ester, (2R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Piperidinecarboxylic acid, 1-methyl-, 2,3,4,5,6-pentafluorophenyl ester, (2R)-(921928-01-0)
• EPA Substance Registry System: 2-Piperidinecarboxylic acid, 1-methyl-, 2,3,4,5,6-pentafluorophenyl ester, (2R)-(921928-01-0)

Safety Data

• Hazardous Substances Data: 921928-01-0(Hazardous Substances Data)

Upstream product

• 771-61-9 2,3,4,5,6-pentafluorophenol 
• 41447-17-0 (R)-1-methylpiperidine-2-carboxylic acid 
• 7730-87-2 1-methylpiperidine-2-carboxylic acid 
• 1723-00-8 (R)-(+)-pipecolic acid 

Downstream Products

• 936691-46-2 (2S,4R)-4-[[2-[(1R,3R)-1-acetoxy-4-methyl-3-[methyl-[(2S,3S)-3-methyl-2-[[(2R)-1-methylpiperidine-2-carbonyl]amino]pentanoyl]amino]pentyl]thiazole-4-carbonyl]amino]-2-methyl-5-phenyl-pentanoic acid 
• 1101181-40-1 C₄₂H₅₉N₅O₆S 
• 1101181-32-1 C₄₂H₅₉N₅O₆S 
• 1017683-85-0 C₃₅H₅₁N₅O₆S 

Relevant articles and documents

CONJUGATION LINKERS CONTAINING 2,3-DIAMINOSUCCINYL GROUP

Provided is a conjugate of a cytotoxic drug/molecule to a cell-binding molecule with a bis-linker (adual-linker) containing a 2, 3-diaminosuccinyl group. It also relates to preparation of the conjugate of a cytotoxic drug/molecule to a cell-binding molecule with the bis-linker, particularly when the drug having functional groups of amino, hydroxyl, diamino, amino-hydroxyl, dihydroxyl, carboxyl, hydrazine, aldehyde and thiol for conjugation with the bis-linker in a specific manner, as well as the therapeutic use of the conjugates.

TUBULYSINS AND PROTEIN-TUBULYSIN CONJUGATES

Provided herein are compounds, compositions, and methods for the treatment of diseases and disorders associated with cancer, including tubulysins and protein (e.g., antibody) drug conjugates thereof.

CONJUGATION OF A CYTOTOXIC DRUG WITH BIS-LINKAGE

What provided is the conjugation of cytotoxic to a cell-binding molecule with a bis-linker(dual-linker) as shown in Formula (I). It provides bis-linkage methods of making a conjugate of a cytotoxic drug molecule to a cell-binding agent in a specific manner. It also relates to application of the conjugates for the treatment of a cancer, or an autoimmune disease, or an infectious disease.