92198-73-7

Usage

Uses

Used in Organic Synthesis:
(1-Tosylpyrrolidine-2,5-diyl)dimethanol is used as a reagent in organic synthesis for its ability to facilitate specific chemical reactions, contributing to the formation of desired products in the synthesis of complex organic molecules.
Used in Pharmaceutical Production:
In the pharmaceutical industry, (1-Tosylpyrrolidine-2,5-diyl)dimethanol is utilized as a key intermediate in the synthesis of various drugs, playing a crucial role in the development of new medicinal compounds.
Used in Dye Production:
(1-Tosylpyrrolidine-2,5-diyl)dimethanol is also employed in the production of dyes, where its chemical properties contribute to the creation of colorants for different applications.
Used in Other Industrial Applications:
Beyond the aforementioned uses, (1-Tosylpyrrolidine-2,5-diyl)dimethanol finds application in a variety of other industrial processes, capitalizing on its unique chemical characteristics to enhance product development and manufacturing efficiency.

Upstream product

• 145472-47-5 (2S,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-1-(toluene-4-sulfonyl)-pyrrolidine-2-carbonitrile 
• 145472-48-6 (S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-1-(toluene-4-sulfonyl)-pyrrolidine-2-carbaldehyde 
• 143264-72-6 N-p-toluenesulphonyl(5-diphenyl-tert-butylsilyloxymethyl)-2-hydroxypyrrolidine 
• 132974-84-6 (-)-(5S)-5-{[(tert-butyldiphenylsilyl)oxy]methyl}-1-tosylpyrrolidin-2-one 
• 145472-49-7 [(S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-1-(toluene-4-sulfonyl)-pyrrolidin-2-yl]-methanol 

Downstream Products

• 145472-51-1 (2S,5S)-2,5-Bis-methoxymethyl-1-(toluene-4-sulfonyl)-pyrrolidine 
• 145472-51-1 (2R,5S)-2,5-Bis-methoxymethyl-1-(toluene-4-sulfonyl)-pyrrolidine 

Relevant academic research and scientific papers

Synthesis and Further Reactivity of Functionalized Lactam-Derived Enol Triflates

Pyrrolidinone- and piperidinone-derived enol triflates 2 were prepared in high yield (60-97%) from the corresponding lactams 1 using KHMDS and N-(5-chloro-2-pyridyl)triflimide. A structure-stability study on the less stable pyrrolidinone-derived triflates revealed that an N-tosyl group is essential, and an α-ethoxy substituent enhances thermal stability. Substituents at the 3- and 4-position are tolerated. Substitution of the triflate moiety by a wide variety of functional groups was achieved under mild conditions via metal-mediated reactions. Although cuprate couplings proceeded in only moderate yields, several palladium-catalyzed reactions gave good yields of interesting molecules for further synthetic operations (for example, Stille coupling with vinylstannanes, cross-coupling with arylzincs, and carbonylation processes). Preparation of the first enantiopure lactam-derived enol triflate 15 (from (S)-pyroglutamic acid) is described. Enamide hydrogenation of derivative 17 allowed the synthesis of a proline analogue 18 in excellent yield and diastereoselectivity (86% de). ? Abstract published in Advance ACS Abstracts, October 15, 1997.

Carbon-Carbon Bond Formation via N-Tosyliminium Ions

Addition of carbon nucleophiles to cyclic N-tosyliminium ions, derived from α-hydroxy and α-methoxy tosylamides (5a,b and 6a,b, respectively) is described.In general, good to excellent yields were obtained when allyltrimethylsilane, 1-t-butyldimethylsilyl