921988-33-2Relevant academic research and scientific papers
Total synthesis of tubulysin U and N14-desacetoxytubulysin H
Cao, Meiqun,Li, Yinghong,Long, Bohua,Tao, Cheng,Wu, Zhengzhi,Zeng, Xiaobin
, p. 5349 - 5353 (2020/08/03)
A concise and efficient procedure for the total synthesis of tubulysin U and N14-desacetoxytubulysin H has been developed with high stereoselectivity on a gram scale. This synthesis features an elegant cascade one-pot process to install the challenging th
Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof
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Page/Page column 94, (2016/02/03)
Antiproliferative compounds having a structure represented by formula (II), where n, R1, R2, R3, R4, and R5 are as defined herein, can be used to treat tumors, optionally when conjugated to a ligand such as an antibody:
Synthesis and biological evaluation of tubulysin D analogs related to stereoisomers of tubuvaline
Shibue, Taku,Okamoto, Iwao,Morita, Nobuyoshi,Morita, Hiroshi,Hirasawa, Yusuke,Hosoya, Takahiro,Tamura, Osamu
supporting information; experimental part, p. 431 - 434 (2011/02/27)
The synthesis and biological evaluation of stereoisomers in tubulysin D are described. The stereoselective synthesis of all possible stereoisomers of C-11 and C-13 positions in tubulysin D was achieved by employing 1′-epi-Tuv-Me, 3′-epi-Tuv-Me, and ent-Tu
Total syntheses of tubulysins
Shibue, Taku,Hirai, Toshihiro,Okamoto, Iwao,Morita, Nobuyoshi,Masu, Hyuma,Azumaya, Isao,Tamura, Osamu
experimental part, p. 11678 - 11688 (2010/11/18)
The total syntheses of tetrapeptides tubulysins D (1b), U (1c), and V (1d), which are potent tubulin polymerization inhibitors, are described. The synthesis of Tuv (2), an unusual amino acid constituent of tubulysins, includes an 1,3-dipolar cycloaddition
Stereoselective synthesis of tubuvaline methyl ester and tubuphenylalanine, components of tubulysins, tubulin polymerization inhibitors
Shibue, Taku,Hirai, Toshihiro,Okamoto, Iwao,Morita, Nobuyoshi,Masu, Hyuma,Azumaya, Isao,Tamura, Osamu
scheme or table, p. 3845 - 3848 (2009/10/11)
Synthetic studies of two components of tubulysins, tubulin polymerization inhibitors are described. The highly stereoselective synthesis of tubuvaline methyl ester (2) was accomplished by 1,3-dipolar cycloaddition of nitrone d-6 and acrylic acid derivativ
