922-54-3Relevant articles and documents
A simple chromatographic route for the isolation of meso diaminopimelic acid
Toth, Gabor K.,Hetenyi, Anasztazia,Ilisz, Istvan,Peter, Antal
experimental part, p. 133 - 137 (2011/11/05)
Meso diaminopimelic acid is an important noncoded amino acid found in Gram-negative bacterial peptidoglycan. In spite of its importance, this stereoisomer is not available commercially. A simple, economical procedure was developed for the isolation of pur
An efficient synthesis of (2S, 6S)- and meso-diaminopimelic acids via asymmetric hydrogenation
Wang,Xiong,Yang,Hruby
, p. 94 - 98 (2007/10/03)
An efficient synthesis of the title compounds 1 and 2 has been successfully developed. The key step is the asymmetric hydrogenation of dehydroamino acid 7 using [Rh(I)(COD)-(S,S) or - (R,R)-Et-DuPHOS)]+OTf- to produce the optically active, protected amino acid derivatives in high ee (>95%). The approach also can be used for the synthesis of other isomers and analogues.
A concise, stereoselective synthesis of meso-2,6-diaminopimelic acid (DAP)
Collier, Philip N.,Patel, Ian,Taylor, Richard J.K.
, p. 5953 - 5954 (2007/10/03)
The preparation of meso-2,6-diaminopimelic acid 1 is described. The key step in the synthesis is Suzuki coupling of the novel organoboron homoalanine equivalent 3 with methyl (2Z)-3-bromo-2-[(tert-butoxycarbonyl)amino]-2-propenoate 5.
