92207-33-5Relevant academic research and scientific papers
Visible-Light-Mediated Rose Bengal-Catalyzed α-Hydroxymethylation of Ketones with Methanol
Yang, Jingya,Xie, Dongtai,Zhou, Hongyan,Chen, Shuwen,Duan, Jiaokui,Huo, Congde,Li, Zheng
supporting information, p. 3471 - 3476 (2018/09/12)
A visible-light-mediated α-hydroxymethylation of ketones using methanol as the hydroxymethylating reagent has been developed. Using 1 mol% rose bengal as the photosensitizer and air as the green oxidant, the reactions proceeded smoothly at room temperature. Experimental studies indicate the reaction proceeded via a radical pathway. (Figure presented.).
Efficient Mukaiyama–Aldol Reaction with Aqueous Formaldehyde on a Hydrophobic Mesoporous Lewis Acid Polymer
Zhang, Fang,Liang, Chao,Wang, Zhen,Li, Hexing
, p. 818 - 824 (2018/01/15)
The design of robust water-compatible solid Lewis acid catalysts in the efficient utilization of aqueous formaldehyde is a challenging task. Herein, we describe an ytterbium triflate containing ordered mesoporous polymer (Yb(OTf)2-MP) that acts as a highly active and selective Lewis acid catalyst for the Mukaiyama–aldol reaction with aqueous formaldehyde. The unique capacity of hydrophobic surface and ordered mesoporosity was able to stabilize the hydrophilic and hydrophobic reactants simultaneously and catalyze the reaction selectively by minimizing water interference at active sites. Accordingly, it enabled a broad range of silyl enol ethers to be used to create structurally diverse β-hydroxy carbonyl molecules efficiently. Notably, the process can be scaled up easily to achieve the gram-scale production of the key intermediate of natural product sarkomycin. Additionally, it is stable under aqueous conditions and can be recovered easily and used repeatedly at least six times.
