92254-03-0

Basic information

• Product Name: 5-METHYLBIPHENYL-2-CARBOXYLIC ACID
• Synonyms: 5-METHYLBIPHENYL-2-CARBOXYLIC ACID
• CAS NO: 92254-03-0
• Molecular Formula: C₁₄H₁₂O₂
• Molecular Weight: 212.24388
• Mol File: 92254-03-0.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-METHYLBIPHENYL-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-METHYLBIPHENYL-2-CARBOXYLIC ACID(92254-03-0)
• EPA Substance Registry System: 5-METHYLBIPHENYL-2-CARBOXYLIC ACID(92254-03-0)

Safety Data

• Hazardous Substances Data: 92254-03-0(Hazardous Substances Data)

Usage

Uses

5-Methyl[1,1''-biphenyl]-2-carboxylic Acid is an intermediate used in the preparation of penicillins which are active against staphylococci.

Upstream product

• 42308-22-5 5-methyl-[1,1'-biphenyl]-2-carbonitrile 
• 7372-85-2 2,5-dimethylbiphenyl 
• 68036-69-1 (E)-2-methyl-4-phenyl-1,3-butadiene 
• 98-80-6 phenylboronic acid 
• 103440-56-8 methyl 2-iodo-4-methylbenzoate 
• 87808-49-9 2-bromo-4-methyl-benzoic acid methyl ester 
• 4670-56-8 methyl 2-hydroxy-4-methylbenzoate 
• 50-85-1 2-hydroxy-p-toluic acid 
• 191104-16-2 2-(trifluoromethanesulfonyloxy)4-methylbenzoic acid methyl ester 
• 191104-38-8 4-methyl-2-phenylbenzoic acid methyl ester 
• 7697-27-0 2-bromo-4-methylbenzoic acid 
• 99-94-5 p-Toluic acid 
• 108-93-0 cyclohexanol 
• 4501-52-4 2-cyclohexyl-p-xylene 

Downstream Products

• 19547-84-3 6β-(5-methyl-biphenyl-2-carbonylamino)-penicillanic acid 

Relevant articles and documents

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Visible-Light-Induced Arene C(sp 2)-H Lactonization Promoted by DDQ and tert -Butyl Nitrite

A visible-light photocatalytic aerobic oxidative lactonization of arene C(sp 2)-H bonds proceeds in the presence of 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) and tert -butyl nitrite (TBN). Under the optimized conditions, a range of 2-arylbenzoic acids is converted into the corresponding benzocoumarin derivatives in moderate to excellent yields. This method is characterized by its atom economy, mild reaction conditions, the use of a green oxidant and metal-free catalysis.

Photocatalytic Dehydrogenative Lactonization of 2-Arylbenzoic Acids

A metal-free dehydrogenative lactonization of 2-arylbenzoic acids at room temperature was developed. This work illustrates the first application of visible-light photoredox catalysis in the preparation of benzo-3,4-coumarins, an important structural motif in bioactive molecules. The combination of photocatalyst [Acr+-Mes] with (NH4)2S2O8 as a terminal oxidant provides an economical and environmentally benign entry to different substituted benzocoumarins. Preliminary mechanistic studies suggest that this reaction most likely occurs through a homolytic aromatic substitution pathway.