923170-94-9

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2,2,2-trifluoroethanol is used as a building block for the synthesis of pharmaceuticals and agrochemicals. Its unique molecular structure and ability to participate in various chemical reactions make it a valuable component in the development of new drugs and agrochemicals.
Used in Medicinal Chemistry and Drug Discovery:
1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2,2,2-trifluoroethanol is used as a key intermediate in medicinal chemistry and drug discovery. Its potential applications in these fields are attributed to its unique molecular structure and its ability to participate in various chemical reactions.
Used in Synthetic Processes:
1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2,2,2-trifluoroethanol is used as a versatile compound in synthetic processes. Its trifluoroethanol moiety provides it with solubility in both organic solvents and water, which can be advantageous in synthetic processes.
Used in Pharmaceutical Formulations:
1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2,2,2-trifluoroethanol is used as a component in the development of pharmaceutical formulations. Its solubility in both organic solvents and water makes it a useful compound in formulating drugs for various routes of administration.

Upstream product

• 1400691-55-5 C₉H₁₆N₂*C₃H₂F₆O₂ 
• 29668-44-8 2,3-dihydro-benzo[1,4]dioxin-6-carbaldehyde 
• 81290-20-2 (trifluoromethyl)trimethylsilane 

Downstream Products

• 122243-34-9 1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2,2,2-trifluoroethan-1-one 

Relevant academic research and scientific papers

Amidinate salt of hexafluoroacetone hydrate for the preparation of fluorinated compounds by the release of trifluoroacetate

A powerful, new reagent, an amidinate salt of hexafluoroacetone hydrate, is an air-stable salt that can be used for the preparation of fluorinated organic molecules. Nucleophilic trifluoromethylation reactions are demonstrated following the base-promoted release of trifluoroacetate. This reagent is soluble in many polar organic solvents and produces fluoroform, following the release of trifluoroacetate. Reactions with this reagent and common electrophiles provide excellent yields of trifluoromethylated products.

Highly efficient synthesis of aryl and heteroaryl trifluoromethyl ketones via o-iodobenzoic acid (IBX)

A two-step process for the synthesis of aryl and heteroaryl trifluoromethyl ketones from the corresponding aldehydes is described. Trifluoromethyl alcohols were prepared from aryl and heteroaryl aldehydes in excellent yields using catalytic amount of K2CO3. The trifluoromethyl alcohols were then oxidized conveniently and efficiently by o-iodoxybenzoic acid (IBX) under mild conditions to get the desired functionalized aryl and heteroaryl trifluoromethyl ketones.

NITROGEN-CONTAINING HETEROCYCLIC COMPOUND HAVING INHIBITORY EFFECT ON PRODUCTION OF KYNURENINE

The present invention provides a nitrogen-containing heterocyclic compound or a pharmaceutically acceptable salt thereof having an inhibitory effect on the production of kynurenine, represented by formula (I): (wherein R6 and R7 may be the same or different and each represent a hydrogen atom or the like, R8, R9, R19, and R11 may be the same or different and each represent a hydrogen atom or the like, R1 represents lower alkyl which may be substituted with cycloalkyl, or the like, and R3 represents optionally substituted aryl or an optionally substituted heterocyclic group).

COMPOSITIONS AND PROCESSES OF PREPARING AND USING THE SAME

The present invention relates to compositions, for example, the DBU/Hexafluoroacetone hydrate salt, and processes of preparing and using the same for the modification of chemical compounds via the release of trifluoroacetate. The DBU/Hexafluoroacetone hydrate salt can perform trifluoromethylation reactions on chemical compounds, such as carbonyl group-containing compounds.