923276-81-7

Basic information

• Product Name: 3-bromo-4-(4-cyanophenyl)-5-(4,4-dimethyl-1,3-oxazolin-2-yl)pyridine
• Synonyms: 3-bromo-4-(4-cyanophenyl)-5-(4,4-dimethyl-1,3-oxazolin-2-yl)pyridine
• CAS NO: 923276-81-7
• Molecular Weight: 356.222
• Mol File: 923276-81-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-bromo-4-(4-cyanophenyl)-5-(4,4-dimethyl-1,3-oxazolin-2-yl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-bromo-4-(4-cyanophenyl)-5-(4,4-dimethyl-1,3-oxazolin-2-yl)pyridine(923276-81-7)
• EPA Substance Registry System: 3-bromo-4-(4-cyanophenyl)-5-(4,4-dimethyl-1,3-oxazolin-2-yl)pyridine(923276-81-7)

Safety Data

• Hazardous Substances Data: 923276-81-7(Hazardous Substances Data)

Upstream product

• 20826-04-4 5-bromo-3-pyridinecarboxylic acid 
• 39620-02-5 5-bromonicotinoyl chloride 
• 35590-37-5 5-bromopyridine-3-carbonitrile 
• 923276-95-3 5-bromo-N-(2-hydroxy-1,1-dimethylethyl)nicotinamide 
• 923276-49-7 3-bromo-5-(4,5-dihydro-4,4-dimethyloxazol-2-yl)pyridine 
• 3058-39-7 4-iodobenzonitrile 

Relevant articles and documents

Unusual sterically controlled regioselective lithiation of 3-bromo-5-(4,4′-dimethyl)oxazolinylpyridine. Straightforward access to highly substituted nicotinic acid derivatives

(Chemical Equation Presented) Lithiation of 5-bromonicotinic acid protected as secondary or tertiary amide as well as (4,4′-dimethyl)oxazoline with lithium amides is reported. The unusual C-2 and C-4 regioselective lithiation of 3-bromo-5-(4,4′-dimethyl)oxazolinylpyridine using LTMP versus LDA was observed, providing a new route to substituted nicotinic acid scaffolds. The methodology was applied to the synthesis of novel C-4 and C-6 arylated 5-bromonicotinic acids.