923601-68-7

Upstream product

• 1247065-58-2 C₁₈H₂₈NO₇P 
• 1774-47-6 trimethylsulfoxonium iodide 
• 3674-18-8 Boc-D-pheO-succinyl 
• 5034-06-0 trimethyl sulfoxonium chloride 
• 1247065-55-9 C₂₁H₂₃NO₆ 
• 1247065-56-0 C₂₂H₂₅NO₆ 
• 16159-70-9 N-tert-butoxycarbonyl D-phenylalanine p-nitrophenyl ester 
• 1247065-61-7 C₁₇H₂₁N₃O₃ 
• 1247065-60-6 C₁₈H₂₁N₃O₅ 
• 1247065-59-3 C₁₈H₂₁N₃O₅ 
• 34101-07-0 (2S)-2-[N-(tert-butoxycarbonyl)amino]-1-imidazol-1-yl-3-phenylpropan-1-one 

Downstream Products

• 150935-37-8 (R)-(1-benzyl-3-chloro-2-oxopropyl)carbamic acid t-butyl ester 

Relevant academic research and scientific papers

PROCESSES FOR THE PREPARATION OF ALPHA-CHLOROKETONES FROM CARBOXYLIC ACIDS

The present disclosure provides compositions and methods for the preparation of ? chloroketones from carboxylic acids. In particular embodiments, the present disclosure provides procedures for the preparation of chiral ? chloroketone derivatives of amino acids.

1-AMINO LINKED COMPOUNDS

The present invention is directed to compounds of formula (I): or a pharmaceutically acceptable salt thereof; wherein A is (II); X is selected from CH, CF and N, R8 is selected from H, C1-C6 alkyl, aryl, heteroaryl, C1-C6 alkylaryl, C1-C6 alkylheteroaryl, C2-C6 alkyl-O- C1-C6 alkyl, C1-C6 haloalkyl, hydroxy C2-C6 alkyl, -C(O)R9 and -SO2R9, or R7 and R8 combine to form (III), (IV); W is selected from CRlO and CR15, RlO is selected from H, halo, -C(O)NR13R14, C1-C6 alkyl, aryl, heteroaryl, C1-C6 alkylaryl, C1-C6 alkylheteroaryl, C1-C6 alkyl-O- C1-C6 alkyl and hydroxy C1-C6 alkyl; Het is a N-linked 5-membered heteroaryl ring optionally substituted with 1-3 substituents selected from methoxy, Cl, F, CH3, CF3, aryl, heteroaryl, C1-C4 alkylaryl or C1-C4 alkylheteroaryl, for use as inhibitors of the DPP-IV enzyme in the treatment or prevention of conditions including Type II diabetes.