923603-92-3Relevant articles and documents
Synthesis of fused heterocycles with a benzazepinone moiety via intramolecular Heck coupling
Joucla, Lionel,Putey, Aurélien,Joseph, Beno?t
, p. 8177 - 8179 (2005)
The preparation of fused heterocycles with a benzazepinone moiety was realised via an intramolecular Heck coupling reaction either at position 2 or at position 3 of the heterocyclic system. This method allowed the synthesis of the pyrrolo[2,3-c]azepinone
Synthesis of latonduine derivatives via intramolecular Heck?reaction
Putey, Aurélien,Joucla, Lionel,Picot, Laurent,Besson, Thierry,Joseph, Beno?t
, p. 867 - 879 (2007/10/03)
The synthesis of indole ring-fused benzazepinone series as latonduine derivatives has been developed via an intramolecular Heck reaction. The scope has been enlarged not only to indole moiety but also to pyrrolo and benzo[b]thiophene nuclei. Several derivatives prepared have been evaluated in vitro for their antiproliferative activities on breast cancer cell lines. Some of them showed promising cytotoxic activities.
