92367-16-3Relevant articles and documents
METHODS FOR MODULATING MACROPHAGE ACTIVITY
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Paragraph 0044, (2020/10/21)
Aspects of the present disclosure include methods for modulating macrophage activity. Methods according to certain embodiments include contacting a macrophage with a mannose receptor (CD206) binding agent in a manner sufficient to modulate activity of the
Distinct metabolites for photoreactive l-phenylalanine derivatives in Klebsiella sp. CK6 isolated from rhizosphere of a wild dipterocarp sapling
Wang, Lei,Hisano, Wataru,Murai, Yuta,Sakurai, Munenori,Muto, Yasuyuki,Ikemoto, Haruka,Okamoto, Masashi,Murotani, Takashi,Isoda, Reika,Kim, Dongyeop,Sakihama, Yasuko,Sitepu, Irnayuli R.,Hashidoko, Yasuyuki,Hatanaka, Yasumaru,Hashimoto, Makoto
, p. 8393 - 8401 (2013/08/23)
Photoaffinity labeling is a reliable analytical method for biological functional analysis. Three major photophores-aryl azide, benzophenone and trifluoromethyldiazirine- are utilized in analysis. Photophore-bearing L-phenylalanine derivatives, which are used for biological functional analysis, were inoculated into a Klebsiella sp. isolated from the rhizosphere of a wild dipterocarp sapling in Central Kalimantan, Indonesia, under nitrogen-limiting conditions. The proportions of metabolites were quite distinct for each photophore. These results indicated that photophores affected substrate recognition in rhizobacterial metabolic pathways, and differential photoaffinity labeling could be achieved using different photophore-containing L-phenylalanine derivatives.
Trifluoromethyldiazirine: An effective photo-induced cross-linking probe for exploring amyloid formation
Smith, David P.,Anderson, Jon,Plante, Jeffrey,Ashcroft, Alison E.,Radford, Sheena E.,Wilson, Andrew J.,Parker, Martin J.
supporting information; experimental part, p. 5728 - 5730 (2009/04/13)
The separative and analytical power of ion mobility spectrometry-mass spectrometry combined with photo-induced cross-linking of site-specifically incorporated trifluoromethyldiazirine provides a powerful approach towards structural characterisation of amy
Simple and versatile method for tagging phenyldiazirine photophores
Nakashima, Hiroyuki,Hashimoto, Makoto,Sadakane, Yutaka,Tomohiro, Takenori,Hatanaka, Yasumaru
, p. 15092 - 15093 (2007/10/03)
The first effective method for the introduction of a versatile substituent on 3-phenyl-3-trifluoromethyldiazirine has been developed. The simple preparation of a useful aldehyde intermediate allows easy access to various elaborated photoaffinity ligands, including a l-phenylalanine analog bearing a diazirine ring (TmdPhe). The asymmetric synthesis of TmdPhe was easily accomplished in gram quantities. Site-directed incorporation of this compound into the structure of a calmodulin-binding peptide using automated peptide synthesis afforded a photoreactive peptide that was successfully used for the specific labeling of calmodulin. Copyright
An efficient route to S-N-(9-fluorenylmethoxycarbonyl)-4′-(1-azi-2,2,2-trifluoroethyl) phenylalanine
Fishwick, Colin W. G.,Sanderson, John M.,Findlay, John B. C.
, p. 4611 - 4614 (2007/10/02)
An extremely efficient synthesis of optically pure photoactivatable phenylalanine derivative 1 is described. The key step involves a highly diastereoselective alkylation of a chiral glycine equivalent.
4'-(1-Azi-2,2,2-trifluoroethyl)phenylalanine, a Photolabile Carbene-Generating Analogue of Phenylalanine
Nassal, Michael
, p. 7540 - 7545 (2007/10/02)
The synthesis and some of the photochemical properties of 4'(1-azi-2,2,2-trifluoroethyl)phenylalanine (7, ATEPhe), a photolabile analogue of phenylalanine, are described.Upon photolysis with wavelengths >300 nm, 7 rapidly eliminates N2, yielding a highly
