92373-98-3Relevant academic research and scientific papers
Biochemical and microbiological evaluation of: N-aryl urea derivatives against mycobacteria and mycobacterial hydrolases
Vartak, Abhishek,Goins, Christopher,De Moura, Vinicius Calado Nogueira,Schreidah, Celine M.,Landgraf, Alexander D.,Lin, Boren,Du, Jianyang,Jackson, Mary,Ronning, Donald R.,Sucheck, Steven J.
, p. 1197 - 1204 (2019/07/25)
A focused library of 24 N-aryl urea derivatives was prepared and evaluated against serine esterases of Mycobacterium tuberculosis (Mtb) Rv3802c and Mtb Ag85C. The members of the library were evaluated for both selectivity and mode of inhibition. Furan-bas
Thiol on silica as a 'catch and release' support for isocyanates to afford ureas
Bolshan, Yuri,Tomaszewski, Miroslaw J.,Santhakumar, Vijayaratnam
, p. 4925 - 4927 (2008/02/08)
Silica-bound thiocarbamates were prepared by Curtius rearrangement of carboxylic acids in the presence of thiol on silica gel. The solid supported thiocarbamates were found to be stable isocyanate equivalents, which upon treatment with amines efficiently afforded di- and tri-substituted ureas. The urea products released from the catch and release support were, in the majority of cases, greater than 95% pure and required no further work up.
An efficient two-step synthesis of mono-, di- and triureas from resin- bound amides
Nefzi, Adel,Ong, Nhi A.,Houghten, Richard A.
, p. 5441 - 5446 (2007/10/03)
An efficient method for the solid-phase synthesis of mono-, di- and triureas from resin-bound mono-amines, diamines and triamines is described. The exhaustive reduction of solid support-bound amides generated the requisite amines, which, following treatme
