923942-36-3

Usage

Uses

Used in Pharmaceutical Industry:
5-Thiazolecarboxylic acid, 2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methyl-, 2-methylpropyl ester is used as a key intermediate in the synthesis of pharmaceutical compounds for various therapeutic applications. Its unique chemical structure allows it to be a valuable component in the development of new drugs, potentially contributing to the treatment of a wide range of medical conditions.
Used in Chemical Industry:
In the chemical industry, 5-Thiazolecarboxylic acid, 2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methyl-, 2-methylpropyl ester serves as a building block for the creation of various organic compounds. Its versatility in chemical reactions and its capacity to form stable derivatives make it an important substance in the synthesis of specialty chemicals, materials, and other complex organic molecules.
Used in Research and Development:
5-Thiazolecarboxylic acid, 2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methyl-, 2-methylpropyl ester is utilized in research settings for the exploration of its chemical properties and potential applications. Its unique structure provides a foundation for studying reaction mechanisms, exploring new synthetic routes, and investigating its interactions with other molecules, which can lead to advancements in both fundamental science and applied research.

Upstream product

• 78-83-1 2-methyl-propan-1-ol 
• 144060-53-7 febuxostat 
• 1312815-36-3 2-(3-formyl-4-isobutyloxy phenyl)-4-methyl-thiazole-5-carboxylic acid isobutyl ester 
• 1312815-35-2 2-(3-formyl-4-hydroxy phenyl)-4-methyl-thiazole-5-carboxylic acid 
• 886501-78-6 2-(4-hydroxy phenyl)-4-methyl-thiazole-5-carboxylic acid 

Downstream Products

• 144060-53-7 febuxostat 

Relevant academic research and scientific papers

Design, synthesis, in silico and in vitro studies of novel 4-methylthiazole-5-carboxylic acid derivatives as potent anti-cancer agents

Since inhibitors of mucin onco proteins are potential targets for breast cancer therapy, a series of novel 4-methylthiazole-5-carboxylic acid (1) derivatives 3a-k were synthesized by the reaction of 1 with SOCl2followed by different bases/alcohols in the presence of triethylamine. Once synthesized and characterized, their binding modes with MUC1 were studied by molecular docking analysis using Aruglab 4.0.1 and QSAR properties were determined using HyperChem. All synthesized compounds were screened for in vitro anti-breast cancer activity against MDA-MB-231 breast adenocarcinoma cell lines by Trypan-blue cell viability assay and MTT methods. Compounds 1, 3b, 3d, 3e, 3i and 3f showed good anti-breast cancer activity. Since 1 and 3d exhibited high potent activity against MDA-MB-231 cell lines, they show could be effective mucin onco protein inhibitors.

PROCESSES FOR THE PREPARATION OF FEBUXOSTAT AND SALTS THEREOF

There is provided a process for preparing febuxostat of formula (I) or a pharmaceutically acceptable salt thereof, the process comprising: condensing a compound of formula (A) with a compound of formula (B) to form an ester of febuxostat; hydrolyzing the ester of febuxostat to febuxostat, and optionally converting the febuxostat to a pharmaceutically acceptable salt thereof, wherein: R' is an activating group selected from boronic acid or lithium; R is selected from optionally substituted C1-4 alkyl or optionally substituted aryl; L is a leaving group selected from diazo, halo, -OSO2R", -OCOR" or -O-Si(R")3; and R" is selected from optionally substituted C1-4 alkyl or optionally substituted aryl.