923977-56-4Relevant academic research and scientific papers
Aqueous Benzylic C-H Trifluoromethylation for Late-Stage Functionalization
Guo, Shuo,AbuSalim, Deyaa I.,Cook, Silas P.
, p. 12378 - 12382 (2018)
The installation of trifluoromethyl groups has become an essential step across a number of industries such as agrochemicals, drug discovery, and materials. Consequently, the rapid introduction of this critical functional group in a predictable fashion would benefit current practitioners in those fields. This communication describes a mild trifluoromethylation of benzylic C-H bonds with high selectivity for the least hindered hydrogen atom. The reaction provides monotrifluoromethylation and proceeds in an environmentally friendly acetone/water solvent system. The method can be used to install benzylic trifluoromethyl groups on highly functionalized drug molecules.
PHENYL COMPOUNDS
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Page/Page column 40, (2010/11/25)
The present invention is directed to compounds of formula (I) or a pharmaceutically acceptable salt thereof; wherein A is (xx) ; X is selected from CH, CF and N, R5 is selected from H, C1-C6 alkyl, C1-C6 fluoroa
