924286-11-3

Upstream product

• 143833-81-2 (Z)-4-(4-methoxybenzyloxy)but-2-en-1-ol 
• 824-94-2 p-methoxybenzyl chloride 
• 77333-26-7 (2R,3S)-threo-3-methylbutane-1,2,4-triol 
• 924286-10-2 (R)-2,2-diethyl-4-[(S)-1-(4-methoxybenzyloxy)propan-2-yl]-1,3-dioxolane 

Downstream Products

• 924286-05-5 (R)-2-[(S)-1-(4-methoxybenzyloxy)propan-2-yl]oxirane 
• 924286-66-8 bis[(9H-fluoren-9-yl)methyl](2S,3S,6S)-1-(4-methoxybenzyloxy)-2-methyl-6-((2S,3S)-3-methyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)heptan-3-yl phosphate 
• 934237-11-3 (2S,3S,6R)-2-[(2S,5S,6S)-5-(1-ethoxyethyloxy)-7-(4-methoxybenzyloxy)-6-methylheptan-2-yl]-6-methoxy-3-methyl-3,6-dihydro-2H-pyran 
• 924286-84-0 6-[4-hydroxy-6-(4-methoxy-benzyloxy)-1,5-dimethyl-hexyl]-5-methyl-5,6-dihydro-2H-pyran-2-ol 
• 924286-65-7 (5S,6S)-6-[(2S,5S,6S)-5-hydroxy-7-(4-methoxybenzyloxy)-6-methylheptan-2-yl]-5-methyl-5,6-dihydropyran-2-one 
• 924286-15-7 (2S,3S,6S)-6-[(2S,3S,6R)-(6-methoxy-3-methyl-3,6-dihydro-2H-pyran-2-yl)-1-(4-methoxybenzyloxy)]-2-methylheptan-3-ol 

Relevant academic research and scientific papers

Total synthesis and evaluation of cytostatin, its C10-C11 diastereomers, and additional key analogues: Impact on PP2A inhibition

The total synthesis of cytostatin, an antitumor agent belonging to the fostriecin family of natural products, is described in full detail. The convergent approach relied on a key epoxide-opening reaction to join the two stereotriad units and a single-step

Ruthenium-catalyzed alkene-alkyne coupling: Synthesis of the proposed structure of amphidinolide A

The ruthenium-catalyzed alkene-alkyne coupling provides a powerful method for the synthesis of 1,4 dienes and a way to simplify synthetic strategy. The latter potential is explored in the context of a synthesis of the assigned structure of amphidinolide A