92444-89-8Relevant academic research and scientific papers
Device and production method for continuously generating 2-chloro-5-trifluoromethylpyridine
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Paragraph 0018, (2021/03/11)
The invention relates to a device for continuously generating 2-chloro-5-trifluoromethylpyridine. The invention also discloses a production method for continuously generating 2-chloro-5-trifluoromethylpyridine. Benzyl chloride is used as a raw material, a
Preparation method of pesticide intermediate 2-chloro-5-methyl pyridine
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Paragraph 0017; 0036; 0039; 0040; 0043; 0046; 0047; 0050, (2019/02/08)
The invention discloses a preparation method of a pesticide intermediate 2-chloro-5-methyl pyridine. The preparation method comprises the following steps: adopting benzyl chloride, ammonia water and n-propanal as a starting material, and adopting a one-pot process to synthesize an intermediate (I); then using ion exchange resin as an acid-binding agent to carry out catalytic reaction, using acetylchloride as an acylation reagent to carry out acetylation, thereby obtaining an intermediate compound (II); and leading the intermediate compound (II), DMF (Dimethyl Formamide) and solid phosgene inan organic solvent to carry out cyclizing ring-closing reaction, thereby obtaining a target compound (I). The preparation method disclosed by the invention has the beneficial effects that the materials are cheap and easy to obtain, the reaction steps are fewer, the process operation is simple, the catalyst can be repeatedly utilized, the emission of three wastes is less, the process is pollution-free and environment-friendly, the product quality is good, the yield is high and the cost is low; the preparation method is very suitable for industrial production and has extremely-strong industrialapplication value.
Preparation method of 2-chloro-5-picoline
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Paragraph 0038; 0039, (2016/11/17)
The invention relates to a preparation method of 2-chloro-5-picoline. According to the method, benzyl chloride is taken as a raw material, benzaldehyde is taken as an inhibitor, ammonia is taken as an aminating agent, a product has a condensation reaction with propionaldehyde under the catalysis of an organic base, then a product has acetylation with an acetylation reagent, finally, a product performs cyclization under actions of N,N-dimethylformamide and triphosgene, and the target product 2-chloro-5-picoline is obtained through purification. The product purity is higher than or equal to 99.5%, and the total molar yield higher than 80% is realized. The preparation method of 2-chloro-5-picoline has good reaction selectivity, high yield and few three wastes, is simple to operate and facilitates industrialized production.
Synthesis and pharmacological properties of 5-alkyl substituted nicotine analogs
Wang, Jing,Li, Xi,Yuan, Qianjia,Ren, Jiangmeng,Huang, Jin,Zeng, Bubing
, p. 2813 - 2818 (2013/08/23)
This paper describes a concise and practical route to enantiomerically enriched 5-alkyl substituted nicotine analogs. The Vilsmeier reaction was used to construct the nicotinaldehydes ring followed by the introduction of the chiral homoallylic alcohol by organic boron reagent and the cyclization of the pyrrolidine ring through the reduction of a chiral azide. 17 analogs have been synthesized and their corresponding biological activities were tested, in which compounds 10d and 10g exhibit excellent IC50 values against RD and SY-SY5Y. Copyright
A Versatile New Synthesis of Quinolines and Related Fused Pyridines. Part 12. A General Synthesis of 2-Chloropyridines and 2-Pyridons
Meth-Cohn, Otto,Westwood, Keith T.
, p. 1173 - 1182 (2007/10/02)
The Vilsmeier formylation of tertiary and secondary enamides leads to 2-pyridons and 2-chloropyridines, respectively.The reaction appears to be quite general allowing substitution in the 1-, 3-, 5-, or 6-position or combinations of these.The major limitation arises with enamides which are unsymmetrically substituted on the double bond with alkyl groups, when mixtures can result.Attempts to introduce a 4-substituent by a variation of the Vilsmeier reagent had limited success.
